Involvement of brain structures in childhood epilepsy with centrotemporal spikes

Yuji Ito, Yuki Maki, Yu Okai, Hiroyuki Kidokoro, Epifanio Bagarinao, Tomoya Takeuchi, Atsuko Ohno, Tomohiko Nakata, Naoko Ishihara, Akihisa Okumura, Hiroyuki Yamamoto, Satoshi Maesawa, Jun Natsume

研究成果: ジャーナルへの寄稿学術論文査読

1 被引用数 (Scopus)


Background: We aimed to investigate electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) findings to elucidate the interictal epileptiform discharge (IED)-related functional alterations in deep brain structures and the neocortex in childhood epilepsy with centrotemporal spikes (CECTS). Methods: Ten children with CECTS (median age 8.2 years), referred to our hospital within a year of onset, were eligible for inclusion. They underwent EEG-fMRI recording during sleep. Llongitudinal evaluations, including medical examinations, intelligence tests, and questionnaires about developmental disabilities, were performed. The initial evaluation was performed at the same time as the EEG-fMRI, and the second evaluation was performed over 2 years after the initial evaluation. Results: Three children were unable to maintain sleep during the EEG-fMRI recording, and the remaining seven children were eligible for further assessment. All patients showed unilateral-dominant centrotemporal spikes during scans. One patient had only positive hemodynamic responses, while the others had both positive and negative hemodynamic responses. All patients showed IED-related hemodynamic responses in the bilateral neocortex. For deep brain structures, IED-related hemodynamic responses were observed in the cingulate gyrus (n = 4), basal ganglia (n = 3), thalamus (n = 2), and default mode network (n = 1). Seizure frequencies at the second evaluation were infrequent or absent, and the longitudinal results of intelligence tests and questionnaires were within normal ranges. Conclusions: We demonstrated that IEDs affect broad brain areas, including deep brain structures such as the cingulate gyrus, basal ganglia, and thalamus. Deep brain structures may play an important role in the pathophysiology of CECTS.

ジャーナルPediatrics International
出版ステータス出版済み - 01-01-2022

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康


「Involvement of brain structures in childhood epilepsy with centrotemporal spikes」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。