Involvement of Ca2+ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts

Terutaka Tsuda, Kozo Kaibuchi, Brian West, Yoshimi Takai

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF-induced expression of the c-myc gene.

本文言語English
ページ(範囲)43-46
ページ数4
ジャーナルFEBS Letters
187
1
DOI
出版ステータスPublished - 22-07-1985
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

フィンガープリント 「Involvement of Ca<sup>2+</sup> in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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