Involvement of DPPIV/CD26 in epithelial morphology and suppressed invasive ability in ovarian carcinoma cells

Hiroaki Kajiyama, Kiyosumi Shibata, Mikio Terauchi, Kazuhiko Ino, Akihiro Nawa, Fumitaka Kikkawa

研究成果: Conference contribution

8 被引用数 (Scopus)

抄録

Dipeptidyl peptidase IV (DPPIV) is a multifunctional cell surface aminopeptidase with ubiquitous expression and it has a variety of functional properties in the development of human malignancies. In the present study, we showed the possible correlation between DPPIV/CD26 expression and less migratory potential with decreased MMP-2 expression in ovarian carcinoma cells. Moreover, induction of DPPIV/CD26 resulted in reduced expressions of MMP-2 and mesenchymal markers such as vimentin and SMA, with a less invasive potential and an epithelial morphologic change. This evidence implies that DPPIV/CD26 may play a crucial role in the antimetastatic potential in ovarian carcinoma.

本文言語English
ホスト出版物のタイトルIntegrated Molecular Medicine for Neuronal and Neoplastic Disorders
出版社Blackwell Publishing Inc.
ページ233-240
ページ数8
ISBN(印刷版)1573316555, 9781573316552
DOI
出版ステータスPublished - 11-2006
外部発表はい

出版物シリーズ

名前Annals of the New York Academy of Sciences
1086
ISSN(印刷版)0077-8923
ISSN(電子版)1749-6632

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

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