Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice

Keiko Tohyama, Toshitaka Nabeshima, Kenji Ichihara, Tsutomu Kameyama

研究成果: Article

25 引用 (Scopus)

抄録

The possible involvement of GABAergic neuronal systems in benzodiazepine(BZP)-induced impairment of a passive avoidance response was investigated. Chlordiazepoxide(CDP) impaired passive avoidance when administered prior to training. The CDP-induced impairment was antagonized by pretreatment with picrotoxin, but not by pretreatment with bicuculline or posttraining administration of picrotoxin. On the contrary, when combined with muscimol, the dose at which CDP impaired the response was lower than the dose at which it did so alone. The synergy of muscimol and CDP was attenuated by pretreatment with flumazenil or bicuculline. From these results, we conclude that GABAergic systems play an important role in the BZP-induced impairment of passive avoidance.

元の言語English
ページ(範囲)22-26
ページ数5
ジャーナルPsychopharmacology
105
発行部数1
DOI
出版物ステータスPublished - 01-03-1991
外部発表Yes

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Avoidance Learning
Chlordiazepoxide
Benzodiazepines
Picrotoxin
Muscimol
Bicuculline
Flumazenil

All Science Journal Classification (ASJC) codes

  • Pharmacology

これを引用

Tohyama, Keiko ; Nabeshima, Toshitaka ; Ichihara, Kenji ; Kameyama, Tsutomu. / Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice. :: Psychopharmacology. 1991 ; 巻 105, 番号 1. pp. 22-26.
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Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice. / Tohyama, Keiko; Nabeshima, Toshitaka; Ichihara, Kenji; Kameyama, Tsutomu.

:: Psychopharmacology, 巻 105, 番号 1, 01.03.1991, p. 22-26.

研究成果: Article

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