Involvement of glycolipid-enriched domains in the transduction mechanism of neurotrophins in cultured neurons

P. Palestini, M. Masserini, G. Bottiroli, J. Brunner, T. Mutoh, A. Ferraretto, D. Ravasi, M. Pitto

研究成果: Short survey査読

5 被引用数 (Scopus)

抄録

Specialized domains, displaying a peculiar lipid and protein composition, are present within the plasma membrane of mammalian cells and play a pivotal role in fundamental membrane-associated events. Among lipids, sphingolipids (in particular glycolipids and sphingomyelin) are characteristically enriched within such domains. Moreover, a series of functionally related proteins is present, suggesting the involvement of these membrane structures in the mechanism of signal transduction and lipid/protein sorting. An increasing body of evidence suggests that domains are dynamic structures, and that their dynamic fluctuations can modulate the activity of domain-associated proteins through changes of glycolipid-protein interaction. Even if a large body of experimental investigation has been carried out on eukaryotic cells, only little attention has been paid to the neuron. The purpose of the present review is to summarize the observations implying a functional role of glycolipid-enriched domains in cultured rat cerebellar granule cells.

本文言語English
ページ(範囲)385-395
ページ数11
ジャーナルBioscience Reports
19
5
DOI
出版ステータスPublished - 1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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