Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats

Taku Nagai, Hiroyuki Kamei, Misato Dohniwa, Masanori Takayanagi, Masakazu Suzuki, Takahiro Matsuya, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

研究成果: Article

22 引用 (Scopus)

抜粋

The role of the phosphorylation of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats was assessed with a delayed spatial win-shift task in a radial arm maze. The task consisted of two phases, a training phase and a test phase, separated by a delay. Phosphorylated extracellular signal-regulated kinase 1/2 levels were significantly and transiently increased in the hippocampus by 60 min, and then returned to the control levels 120 min after the training phase. Bilateral microinjections of the PD98059, an inhibitor of the extracellular signal-regulated kinase 1/2 kinase MEK, into the hippocampus impaired performance in the test phase of the delayed spatial win-shift task at 5-min delay. These results suggest that extracellular signal-regulated kinase 1/2 activation in the hippocampus plays a crucial role in spatial working memory.

元の言語English
ページ(範囲)1453-1457
ページ数5
ジャーナルNeuroReport
17
発行部数13
DOI
出版物ステータスPublished - 01-09-2006
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Nagai, T., Kamei, H., Dohniwa, M., Takayanagi, M., Suzuki, M., Matsuya, T., Nabeshima, T., Takuma, K., & Yamada, K. (2006). Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats. NeuroReport, 17(13), 1453-1457. https://doi.org/10.1097/01.wnr.0000233095.74913.88