Involvement of nitric oxide in phencyclidine-induced place aversion and preference in mice

Yoshiaki Miyamoto, Yukihiro Noda, Yumiko Komori, Hishayoshi Sugihara, Hiroshi Furukawa, Toshitaka Nabeshima

研究成果: Article

10 引用 (Scopus)

抄録

The present study investigated the involvement of nitric oxide (NO) in phencyclidine (PCP)-induced place aversion and preference in the place conditioning paradigm. PCP-induced place aversion in naive mice was dose-dependently attenuated by administration of N(G)-nitro-L-arginine methyl ester (L-NAME), a NO synthase (NOS) inhibitor, during the conditioning. The NOS activity and dopamine (DA) turnover in the hippocampus in mice showing PCP-induced place aversion were decreased, such changes being restored by administration of L-NAME during the conditioning. On the other hand, PCP-induced place preference in mice pretreated with PCP for 28 days was not attenuated by administration of L-NAME during the conditioning. Although NOS activity was not changed, the DA turnover in the cerebral cortex was increased in mice showing PCP-induced place preference. In mice pretreated with L-NAME and PCP for 28 days before the place conditioning paradigm, PCP neither induced place preference, nor changed the NOS activity or DA turnover. These results suggest that NO is involved in the acquisition of PCP-induced aversive effects, and in the development of PCP-induced preferred effects. Further, the functional change of the DAergic neuronal system mediated by NO in the hippocampus and cerebral cortex may be necessary for the expression of aversive effects and development of preferred effects, respectively, induced by PCP. (C) 2000 Elsevier Science B.V.

元の言語English
ページ(範囲)187-196
ページ数10
ジャーナルBehavioural Brain Research
116
発行部数2
DOI
出版物ステータスPublished - 05-12-2000
外部発表Yes

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Phencyclidine
NG-Nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Synthase
Dopamine
Cerebral Cortex
Hippocampus

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

これを引用

Miyamoto, Yoshiaki ; Noda, Yukihiro ; Komori, Yumiko ; Sugihara, Hishayoshi ; Furukawa, Hiroshi ; Nabeshima, Toshitaka. / Involvement of nitric oxide in phencyclidine-induced place aversion and preference in mice. :: Behavioural Brain Research. 2000 ; 巻 116, 番号 2. pp. 187-196.
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abstract = "The present study investigated the involvement of nitric oxide (NO) in phencyclidine (PCP)-induced place aversion and preference in the place conditioning paradigm. PCP-induced place aversion in naive mice was dose-dependently attenuated by administration of N(G)-nitro-L-arginine methyl ester (L-NAME), a NO synthase (NOS) inhibitor, during the conditioning. The NOS activity and dopamine (DA) turnover in the hippocampus in mice showing PCP-induced place aversion were decreased, such changes being restored by administration of L-NAME during the conditioning. On the other hand, PCP-induced place preference in mice pretreated with PCP for 28 days was not attenuated by administration of L-NAME during the conditioning. Although NOS activity was not changed, the DA turnover in the cerebral cortex was increased in mice showing PCP-induced place preference. In mice pretreated with L-NAME and PCP for 28 days before the place conditioning paradigm, PCP neither induced place preference, nor changed the NOS activity or DA turnover. These results suggest that NO is involved in the acquisition of PCP-induced aversive effects, and in the development of PCP-induced preferred effects. Further, the functional change of the DAergic neuronal system mediated by NO in the hippocampus and cerebral cortex may be necessary for the expression of aversive effects and development of preferred effects, respectively, induced by PCP. (C) 2000 Elsevier Science B.V.",
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Involvement of nitric oxide in phencyclidine-induced place aversion and preference in mice. / Miyamoto, Yoshiaki; Noda, Yukihiro; Komori, Yumiko; Sugihara, Hishayoshi; Furukawa, Hiroshi; Nabeshima, Toshitaka.

:: Behavioural Brain Research, 巻 116, 番号 2, 05.12.2000, p. 187-196.

研究成果: Article

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AU - Miyamoto, Yoshiaki

AU - Noda, Yukihiro

AU - Komori, Yumiko

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AU - Furukawa, Hiroshi

AU - Nabeshima, Toshitaka

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