Involvement of spinal and supraspinal structures in tizanidine-induced antinociceptive action

Toshitaka Nabeshima, Kiyoshi Matsuno, Tsutomu Kameyama

研究成果: Article査読

14 被引用数 (Scopus)

抄録

The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino)2,1,3-benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and morphine. Tizanidine and clonidine produced a profound and linear dose-dependent antinociceptive action by i.c.v. administration. The ED511 values for tizanidine, clonidine and morphine were increased 2-4-fold 1 or 3 days after spinalization at C5-C6. These results indicate that the antinociceptive activity of tizanidine arises mainly from activity at the supraspinal level, similar to clonidine and morphine, but these drugs act also at the spinal level at high doses.

本文言語English
ページ(範囲)1-4
ページ数4
ジャーナルNeuroscience Letters
63
1
DOI
出版ステータスPublished - 02-01-1986
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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