TY - JOUR
T1 - Involvement of the serotonergic neuronal system in phencyclidine-induced place aversion in rats
AU - Kitaichi, Kiyoyuki
AU - Noda, Yukihiro
AU - Miyamoto, Yoshiaki
AU - Numaguchi, Atsushi
AU - Osawa, Hirokatsu
AU - Hasegawa, Takaaki
AU - Furukawa, Hiroshi
AU - Nabeshima, Toshitaka
N1 - Funding Information:
We are grateful to Janssen Kyowa Co. Ltd. for the gift of ritanserin. This research was partly supported by a Grant for Drug Abuse Research from The Ministry of Health and Welfare of Japan, grants from the Ministry of Education, Science and Culture, Japan (#08457027 and #10044260) and a Sasakawa Scientific Research Grant (9-220).
PY - 1999/8
Y1 - 1999/8
N2 - The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasegawa T, Furukawa H, Nabeshima T. Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats. Eur J Pharmacol 1996;318:7-9). The blockade of serotonin(2A) (5-HT(2A)) receptors using the antagonist ritanserin (3 and 10 mg/kg, p.o) significantly attenuated this aversive property of PCP whereas lesions of serotonergic neurons using 5,7-dihydroxytryptamine (5,7-DHT, 100 μg/animal, i.c.v.) failed to affect it. Repeated PCP treatment (10 mg/kg, i.p. for 14 days), which is enough to diminish the stereotyped 5-HT(2A) receptor-mediated head-twitch behavior, also decreased the place aversion. These results suggest that the serotonergic neuronal system, specifically the 5-HT(2A) receptor, may play a critical role in producing PCP-induced place aversion.
AB - The possible involvement of the serotonergic neuronal system in aversive motivation produced by phencyclidine [1-(1-phenylcyclohexyl)piperidine; PCP] was investigated using a place-conditioning paradigm in rats. PCP (4 mg/kg, i.p.) produced place aversion in this task as reported previously (Kitaichi K, Noda Y, Hasegawa T, Furukawa H, Nabeshima T. Acute phencyclidine induces aversion, but repeated phencyclidine induces preference in the place conditioning test in rats. Eur J Pharmacol 1996;318:7-9). The blockade of serotonin(2A) (5-HT(2A)) receptors using the antagonist ritanserin (3 and 10 mg/kg, p.o) significantly attenuated this aversive property of PCP whereas lesions of serotonergic neurons using 5,7-dihydroxytryptamine (5,7-DHT, 100 μg/animal, i.c.v.) failed to affect it. Repeated PCP treatment (10 mg/kg, i.p. for 14 days), which is enough to diminish the stereotyped 5-HT(2A) receptor-mediated head-twitch behavior, also decreased the place aversion. These results suggest that the serotonergic neuronal system, specifically the 5-HT(2A) receptor, may play a critical role in producing PCP-induced place aversion.
UR - http://www.scopus.com/inward/record.url?scp=0032885082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032885082&partnerID=8YFLogxK
U2 - 10.1016/S0166-4328(99)00029-7
DO - 10.1016/S0166-4328(99)00029-7
M3 - Article
C2 - 10475170
AN - SCOPUS:0032885082
SN - 0166-4328
VL - 103
SP - 105
EP - 111
JO - Behavioural Brain Research
JF - Behavioural Brain Research
IS - 1
ER -