IQGAP1: A key regulator of adhesion and migration

Jun Noritake, Takashi Watanabe, Kazumasa Sato, Shujie Wang, Kozo Kaibuchi

研究成果: Article査読

272 被引用数 (Scopus)

抄録

The dynamic rearrangement of cell-cell adhesion is one of the major physiological events in tissue development and tumor metastasis. Polarized cell migration, another key event, is a tightly regulated process that occurs during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively. It captures and stabilizes microtubules through the microtubule-binding protein CLIP-170 near the cell cortex, leading to establishment of polarized cell morphology and directional cell migration. Furthermore, Rac1 and Cdc42 link the adenomatous; polyposis coli (APC) protein to actin filaments through IQGAP1 at the leading edge and thereby regulate polarization and directional migration.

本文言語English
ページ(範囲)2085-2092
ページ数8
ジャーナルJournal of cell science
118
10
DOI
出版ステータスPublished - 15-05-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Cell Biology

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