Irreversible inhibition of metallo-β-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)-propionic acid pentafluorophenyl ester

Hiromasa Kurosaki; Yoshihiro Yamaguchi; Toshihiro Higashi; Kimitaka Soga; Satoshi Matsueda; Haruka Yumoto; Shogo Misumi; Yuriko Yamagata; Yoshichika Arakawa; Masafumi Goto

doi:10.1002/anie.200500835

Irreversible inhibition of metallo-β-lactamase (IMP-1) by 3-(3-mercaptopropionylsulfanyl)-propionic acid pentafluorophenyl ester

Hiromasa Kurosaki
, Yoshihiro Yamaguchi
, Toshihiro Higashi
, Kimitaka Soga
, Satoshi Matsueda
, Haruka Yumoto
, Shogo Misumi
, Yuriko Yamagata
, Yoshichika Arakawa
, Masafumi Goto

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

66 被引用数 (Scopus)

抄録

Resistance is futile: Pathogenic bacteria that produce metallo-β- lactamases are recognized as a serious threat because of their resistance to antibiotics. The title compound has now been shown to be an irreversible inhibitor for a metallo-β-lactamase (IMP-1). The X-ray crystallographic structure (see picture) has revealed that the inhibitor binds to IMP-1 with formation of a covalent amide bond with the amino group (N^ζ) of Lys 224. (Figure Presented)

本文言語	英語
ページ（範囲）	3861-3864
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	44
号	25
DOI	https://doi.org/10.1002/anie.200500835
出版ステータス	出版済み - 20-06-2005
外部発表	はい

All Science Journal Classification (ASJC) codes

触媒
化学一般

文献へのアクセス

10.1002/anie.200500835

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引用スタイル

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abstract = "Resistance is futile: Pathogenic bacteria that produce metallo-β- lactamases are recognized as a serious threat because of their resistance to antibiotics. The title compound has now been shown to be an irreversible inhibitor for a metallo-β-lactamase (IMP-1). The X-ray crystallographic structure (see picture) has revealed that the inhibitor binds to IMP-1 with formation of a covalent amide bond with the amino group (Nζ) of Lys 224. (Figure Presented)",

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AU - Higashi, Toshihiro

AU - Soga, Kimitaka

AU - Matsueda, Satoshi

AU - Yumoto, Haruka

AU - Misumi, Shogo

AU - Yamagata, Yuriko

AU - Arakawa, Yoshichika

AU - Goto, Masafumi

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