Is the volume of the parathyroid gland a predictor of maxacalcitol response in advanced secondary hyperparathyroidism?

Yoshihiro Tominaga, Daijo Inaguma, Susumu Matsuoka, Hideki Tahara, Kazutaka Kukita, Satoshi Kurihara, Noritaka Onoda, Yoshinari Tsuruta, Syuichi Tsutsui, Kazumichi Ohta, Morimasa Kuwahara, Motoko Tanaka, Yoshiki Nishizawa

研究成果: Article

35 引用 (Scopus)

抄録

We evaluated the relationship between the volume of parathyroid glands estimated by ultrasonography (US) and response of 22-oxa calcitriol (Maxacalcitol, OCT) in patients with secondary hyperparathyroidism (2HPT) to evaluate whether the volume can be a predictor of the OCT response. Eleven institutes participated in this study. Ninety-four patients with advanced 2HPT were enrolled. The volume of the parathyroid glands were estimated by US before and 6 months after OCT treatment. The response of OCT treatment was classified into three groups (Group A: i-PTH < 300 pg/mL; Group B: 300 pg/mL ≤ i-PTH < 500 pg/mL; Group C: i-PTH ≥ 500 pg/mL). Forty-eight patients were in Group A, 28 patients in Group B, and 18 patients in Group C. The PTH levels at the beginning and 6 months were 458.3-199.1 pg/mL (P < 0.0001) in Group A, 524.6-403.2 pg/mL (P = 0.007) in Group B and 736.7-613.6 pg/mL (ns) in Group C, respectively. The volume of the largest gland in Group B was significantly larger than that in Group A (96.2 vs. 343.2 mm3: P < 0.001). Clinical factors affecting response of OCT was evaluated by logistic regression analysis and only the volume of the largest gland was a significant factor. In the patients whose volume was less than 300 mm3, the OCT response was significantly effective. We conclude that the glandular volume of the largest parathyroid gland estimated by US can be a useful factor to predict the OCT response in patients with moderate or severe renal HPT.

元の言語English
ページ(範囲)198-204
ページ数7
ジャーナルTherapeutic Apheresis and Dialysis
10
発行部数2
DOI
出版物ステータスPublished - 01-04-2006
外部発表Yes

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Secondary Hyperparathyroidism
Parathyroid Glands
Ultrasonography
maxacalcitol
Logistic Models
Regression Analysis
Kidney
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Nephrology

これを引用

Tominaga, Yoshihiro ; Inaguma, Daijo ; Matsuoka, Susumu ; Tahara, Hideki ; Kukita, Kazutaka ; Kurihara, Satoshi ; Onoda, Noritaka ; Tsuruta, Yoshinari ; Tsutsui, Syuichi ; Ohta, Kazumichi ; Kuwahara, Morimasa ; Tanaka, Motoko ; Nishizawa, Yoshiki. / Is the volume of the parathyroid gland a predictor of maxacalcitol response in advanced secondary hyperparathyroidism?. :: Therapeutic Apheresis and Dialysis. 2006 ; 巻 10, 番号 2. pp. 198-204.
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abstract = "We evaluated the relationship between the volume of parathyroid glands estimated by ultrasonography (US) and response of 22-oxa calcitriol (Maxacalcitol, OCT) in patients with secondary hyperparathyroidism (2HPT) to evaluate whether the volume can be a predictor of the OCT response. Eleven institutes participated in this study. Ninety-four patients with advanced 2HPT were enrolled. The volume of the parathyroid glands were estimated by US before and 6 months after OCT treatment. The response of OCT treatment was classified into three groups (Group A: i-PTH < 300 pg/mL; Group B: 300 pg/mL ≤ i-PTH < 500 pg/mL; Group C: i-PTH ≥ 500 pg/mL). Forty-eight patients were in Group A, 28 patients in Group B, and 18 patients in Group C. The PTH levels at the beginning and 6 months were 458.3-199.1 pg/mL (P < 0.0001) in Group A, 524.6-403.2 pg/mL (P = 0.007) in Group B and 736.7-613.6 pg/mL (ns) in Group C, respectively. The volume of the largest gland in Group B was significantly larger than that in Group A (96.2 vs. 343.2 mm3: P < 0.001). Clinical factors affecting response of OCT was evaluated by logistic regression analysis and only the volume of the largest gland was a significant factor. In the patients whose volume was less than 300 mm3, the OCT response was significantly effective. We conclude that the glandular volume of the largest parathyroid gland estimated by US can be a useful factor to predict the OCT response in patients with moderate or severe renal HPT.",
author = "Yoshihiro Tominaga and Daijo Inaguma and Susumu Matsuoka and Hideki Tahara and Kazutaka Kukita and Satoshi Kurihara and Noritaka Onoda and Yoshinari Tsuruta and Syuichi Tsutsui and Kazumichi Ohta and Morimasa Kuwahara and Motoko Tanaka and Yoshiki Nishizawa",
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Tominaga, Y, Inaguma, D, Matsuoka, S, Tahara, H, Kukita, K, Kurihara, S, Onoda, N, Tsuruta, Y, Tsutsui, S, Ohta, K, Kuwahara, M, Tanaka, M & Nishizawa, Y 2006, 'Is the volume of the parathyroid gland a predictor of maxacalcitol response in advanced secondary hyperparathyroidism?', Therapeutic Apheresis and Dialysis, 巻. 10, 番号 2, pp. 198-204. https://doi.org/10.1111/j.1744-9987.2006.00364.x

Is the volume of the parathyroid gland a predictor of maxacalcitol response in advanced secondary hyperparathyroidism? / Tominaga, Yoshihiro; Inaguma, Daijo; Matsuoka, Susumu; Tahara, Hideki; Kukita, Kazutaka; Kurihara, Satoshi; Onoda, Noritaka; Tsuruta, Yoshinari; Tsutsui, Syuichi; Ohta, Kazumichi; Kuwahara, Morimasa; Tanaka, Motoko; Nishizawa, Yoshiki.

:: Therapeutic Apheresis and Dialysis, 巻 10, 番号 2, 01.04.2006, p. 198-204.

研究成果: Article

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T1 - Is the volume of the parathyroid gland a predictor of maxacalcitol response in advanced secondary hyperparathyroidism?

AU - Tominaga, Yoshihiro

AU - Inaguma, Daijo

AU - Matsuoka, Susumu

AU - Tahara, Hideki

AU - Kukita, Kazutaka

AU - Kurihara, Satoshi

AU - Onoda, Noritaka

AU - Tsuruta, Yoshinari

AU - Tsutsui, Syuichi

AU - Ohta, Kazumichi

AU - Kuwahara, Morimasa

AU - Tanaka, Motoko

AU - Nishizawa, Yoshiki

PY - 2006/4/1

Y1 - 2006/4/1

N2 - We evaluated the relationship between the volume of parathyroid glands estimated by ultrasonography (US) and response of 22-oxa calcitriol (Maxacalcitol, OCT) in patients with secondary hyperparathyroidism (2HPT) to evaluate whether the volume can be a predictor of the OCT response. Eleven institutes participated in this study. Ninety-four patients with advanced 2HPT were enrolled. The volume of the parathyroid glands were estimated by US before and 6 months after OCT treatment. The response of OCT treatment was classified into three groups (Group A: i-PTH < 300 pg/mL; Group B: 300 pg/mL ≤ i-PTH < 500 pg/mL; Group C: i-PTH ≥ 500 pg/mL). Forty-eight patients were in Group A, 28 patients in Group B, and 18 patients in Group C. The PTH levels at the beginning and 6 months were 458.3-199.1 pg/mL (P < 0.0001) in Group A, 524.6-403.2 pg/mL (P = 0.007) in Group B and 736.7-613.6 pg/mL (ns) in Group C, respectively. The volume of the largest gland in Group B was significantly larger than that in Group A (96.2 vs. 343.2 mm3: P < 0.001). Clinical factors affecting response of OCT was evaluated by logistic regression analysis and only the volume of the largest gland was a significant factor. In the patients whose volume was less than 300 mm3, the OCT response was significantly effective. We conclude that the glandular volume of the largest parathyroid gland estimated by US can be a useful factor to predict the OCT response in patients with moderate or severe renal HPT.

AB - We evaluated the relationship between the volume of parathyroid glands estimated by ultrasonography (US) and response of 22-oxa calcitriol (Maxacalcitol, OCT) in patients with secondary hyperparathyroidism (2HPT) to evaluate whether the volume can be a predictor of the OCT response. Eleven institutes participated in this study. Ninety-four patients with advanced 2HPT were enrolled. The volume of the parathyroid glands were estimated by US before and 6 months after OCT treatment. The response of OCT treatment was classified into three groups (Group A: i-PTH < 300 pg/mL; Group B: 300 pg/mL ≤ i-PTH < 500 pg/mL; Group C: i-PTH ≥ 500 pg/mL). Forty-eight patients were in Group A, 28 patients in Group B, and 18 patients in Group C. The PTH levels at the beginning and 6 months were 458.3-199.1 pg/mL (P < 0.0001) in Group A, 524.6-403.2 pg/mL (P = 0.007) in Group B and 736.7-613.6 pg/mL (ns) in Group C, respectively. The volume of the largest gland in Group B was significantly larger than that in Group A (96.2 vs. 343.2 mm3: P < 0.001). Clinical factors affecting response of OCT was evaluated by logistic regression analysis and only the volume of the largest gland was a significant factor. In the patients whose volume was less than 300 mm3, the OCT response was significantly effective. We conclude that the glandular volume of the largest parathyroid gland estimated by US can be a useful factor to predict the OCT response in patients with moderate or severe renal HPT.

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