Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells

Koji Ohira, Takahiro Furuta, Hiroyuki Hioki, Kouichi C. Nakamura, Eriko Kuramoto, Yasuyo Tanaka, Nobuo Funatsu, Keiko Shimizu, Takao Oishi, Motoharu Hayashi, Tsuyoshi Miyakawa, Takeshi Kaneko, Shun Nakamura

研究成果: Article査読

169 被引用数 (Scopus)

抄録

Adult mammalian neurogenesis occurs in the hippocampus and the olfactory bulb, whereas neocortical adult neurogenesis remains controversial. Several occurrences of neocortical adult neurogenesis in injured neocortex were recently reported, suggesting that neural stem cells (NSCs) or neuronal progenitor cells (NPCs) that can be activated by injury are maintained in the adult brain. However, it is not clear whether or where neocortical NSCs/NPCs exist in the brain. We found NPCs in the neocortical layer 1 of adult rats and observed that their proliferation was highly activated by global forebrain ischemia. Using retrovirus-mediated labeling of layer 1 proliferating cells with membrane-targeted green fluorescent protein, we found that the newly generated neurons were GABAergic and that the neurons were functionally integrated into the neuronal circuitry. Our results suggest that layer 1 NPCs are a source of adult neurogenesis under ischemic conditions.

本文言語English
ページ(範囲)173-179
ページ数7
ジャーナルNature Neuroscience
13
2
DOI
出版ステータスPublished - 18-02-2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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