TY - JOUR
T1 - Ischemic tolerance in the cochlea
AU - Takeda, Shoichiro
AU - Hata, Ryuji
AU - Cao, Fang
AU - Yoshida, Tadashi
AU - Hakuba, Nobuhiro
AU - Hato, Naohito
AU - Gyo, Kiyofumi
N1 - Funding Information:
The present study was supported in part by Grant-in-Aid for Young Scientists (B) (no. 20791199), and Grant-in-Aid for Scientific Research (B) (no. 20390442), Ministry of Education, Science, Sports and Culture, Japan.
PY - 2009/9/25
Y1 - 2009/9/25
N2 - Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.
AB - Ischemic tolerance in the cochlea was investigated in a gerbil model of cochlear ischemia. Transient cochlear ischemia was produced by extracranial occlusion of the bilateral vertebral arteries. The gerbils were divided into two groups; single ischemia group and double ischemia group. In the single ischemia group, animals were subjected to lethal cochlear ischemia for 15 min. In the double ischemia group, animals were subjected to sublethal cochlear ischemia for 2 min at 2 days before lethal ischemia for 15 min. Consequently, sublethal ischemia prevented lethal ischemia-induced hair cell degeneration and ameliorated hearing impairment, suggesting ischemic tolerance in the cochlea.
UR - https://www.scopus.com/pages/publications/67849109647
UR - https://www.scopus.com/pages/publications/67849109647#tab=citedBy
U2 - 10.1016/j.neulet.2009.07.019
DO - 10.1016/j.neulet.2009.07.019
M3 - Article
C2 - 19596048
AN - SCOPUS:67849109647
SN - 0304-3940
VL - 462
SP - 263
EP - 266
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 3
ER -