'Ischemic tolerance' phenomenon found in the brain

Kazuo Kitagawa, Masayasu Matsumoto, Masafumi Tagaya, Ryuji Hata, Hirokazu Ueda, Michio Niinobe, Nobuo Handa, Ryuzo Fukunaga, Kazufumi Kimura, Katsuhiko Mikoshiba, Takenobu Kamada

研究成果: Article

1002 引用 (Scopus)

抄録

We investigated the possibility that neuronal cells given a mild ischemic treatment sufficient to perturb the cellular metabolism acquired tolerance to a subsequent, and what would be lethal, ischemic stress in vivo. Cerebral ischemia was produced in the gerbils by occlusion of both common carotids for 5 min, which consistently resulted in delayed neuronal death in the CA1 region of the hippocampus. Minor 2-min ischemia in this model depletes high-energy phosphate compounds and perturbs the protein synthesis, but nerver causes neuronal necrosis, and therefore was chosen as mild ischemic treatment. Single 2-min ischemia 1 day or 2 days before 5 min ischemia exhibited only partial protective effects against delayed neuronal death. However, two 2-min ischemic treatments at 1 day intervals 2 days before 5 min ischemia exhibited drastically complete protection against neuronal death. The duration and intervals of ischemic treatment, enough to perturb cellular metabolism and cause protein syhthesis, were needed respectively, because neither 1-min ischemia nor 2-min ischemia received twice at short intervals exhibited protective effects. This 'ischemic tolerance' phenomenon induced by ischemic stress - which is unquestionably important - and frequent stress in clinical medicine, is intriguing and may open a new approach to investigate the pathophysiology of ischemic neuronal damage.

元の言語English
ページ(範囲)21-24
ページ数4
ジャーナルBrain Research
528
発行部数1
DOI
出版物ステータスPublished - 24-09-1990

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Ischemia
Brain
Gerbillinae
Clinical Medicine
Brain Ischemia
Hippocampus
Proteins
Necrosis
Phosphates

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

これを引用

Kitagawa, K., Matsumoto, M., Tagaya, M., Hata, R., Ueda, H., Niinobe, M., ... Kamada, T. (1990). 'Ischemic tolerance' phenomenon found in the brain. Brain Research, 528(1), 21-24. https://doi.org/10.1016/0006-8993(90)90189-I
Kitagawa, Kazuo ; Matsumoto, Masayasu ; Tagaya, Masafumi ; Hata, Ryuji ; Ueda, Hirokazu ; Niinobe, Michio ; Handa, Nobuo ; Fukunaga, Ryuzo ; Kimura, Kazufumi ; Mikoshiba, Katsuhiko ; Kamada, Takenobu. / 'Ischemic tolerance' phenomenon found in the brain. :: Brain Research. 1990 ; 巻 528, 番号 1. pp. 21-24.
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Kitagawa, K, Matsumoto, M, Tagaya, M, Hata, R, Ueda, H, Niinobe, M, Handa, N, Fukunaga, R, Kimura, K, Mikoshiba, K & Kamada, T 1990, ''Ischemic tolerance' phenomenon found in the brain', Brain Research, 巻. 528, 番号 1, pp. 21-24. https://doi.org/10.1016/0006-8993(90)90189-I

'Ischemic tolerance' phenomenon found in the brain. / Kitagawa, Kazuo; Matsumoto, Masayasu; Tagaya, Masafumi; Hata, Ryuji; Ueda, Hirokazu; Niinobe, Michio; Handa, Nobuo; Fukunaga, Ryuzo; Kimura, Kazufumi; Mikoshiba, Katsuhiko; Kamada, Takenobu.

:: Brain Research, 巻 528, 番号 1, 24.09.1990, p. 21-24.

研究成果: Article

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AU - Handa, Nobuo

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AU - Kamada, Takenobu

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Kitagawa K, Matsumoto M, Tagaya M, Hata R, Ueda H, Niinobe M その他. 'Ischemic tolerance' phenomenon found in the brain. Brain Research. 1990 9 24;528(1):21-24. https://doi.org/10.1016/0006-8993(90)90189-I