'Ischemic tolerance' phenomenon found in the brain

Kazuo Kitagawa, Masayasu Matsumoto, Masafumi Tagaya, Ryuji Hata, Hirokazu Ueda, Michio Niinobe, Nobuo Handa, Ryuzo Fukunaga, Kazufumi Kimura, Katsuhiko Mikoshiba, Takenobu Kamada

研究成果: Article

1007 引用 (Scopus)


We investigated the possibility that neuronal cells given a mild ischemic treatment sufficient to perturb the cellular metabolism acquired tolerance to a subsequent, and what would be lethal, ischemic stress in vivo. Cerebral ischemia was produced in the gerbils by occlusion of both common carotids for 5 min, which consistently resulted in delayed neuronal death in the CA1 region of the hippocampus. Minor 2-min ischemia in this model depletes high-energy phosphate compounds and perturbs the protein synthesis, but nerver causes neuronal necrosis, and therefore was chosen as mild ischemic treatment. Single 2-min ischemia 1 day or 2 days before 5 min ischemia exhibited only partial protective effects against delayed neuronal death. However, two 2-min ischemic treatments at 1 day intervals 2 days before 5 min ischemia exhibited drastically complete protection against neuronal death. The duration and intervals of ischemic treatment, enough to perturb cellular metabolism and cause protein syhthesis, were needed respectively, because neither 1-min ischemia nor 2-min ischemia received twice at short intervals exhibited protective effects. This 'ischemic tolerance' phenomenon induced by ischemic stress - which is unquestionably important - and frequent stress in clinical medicine, is intriguing and may open a new approach to investigate the pathophysiology of ischemic neuronal damage.

ジャーナルBrain Research
出版物ステータスPublished - 24-09-1990

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Kitagawa, K., Matsumoto, M., Tagaya, M., Hata, R., Ueda, H., Niinobe, M., Handa, N., Fukunaga, R., Kimura, K., Mikoshiba, K., & Kamada, T. (1990). 'Ischemic tolerance' phenomenon found in the brain. Brain Research, 528(1), 21-24. https://doi.org/10.1016/0006-8993(90)90189-I