Isolation of ret proto-oncogene cDNA with a an amino-terminal signal sequence

M. Takahashi, Y. Buma, H. Hiai

研究成果: Article査読

126 被引用数 (Scopus)

抄録

Our recent studies suggested that the ret proto-oncogene protein is a cell surface receptor with a tyrosine kinase domain. However, the sequence of its cDNA lacked an amino-terminal signal sequence characteristic of membrane proteins. In the present study we have isolated and sequenced an additional cDNA clone. The nucleotide sequence of the cDNA obtained indicated that the 5' terminal 330 nucleotides differs from the published sequence of the ret proto-oncogene. In addition, the sequence contains an open reading frame with an amino-terminal signal sequence.

本文言語English
ページ(範囲)805-806
ページ数2
ジャーナルOncogene
4
6
出版ステータスPublished - 01-01-1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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