Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial

J-MINT study group

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

INTRODUCTION: We examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI). METHODS: Participants aged 65-85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months. RESULTS: Of 531 participants, 406 completed the trial. The between-group difference in composite score changes was 0.047 (95% CI: −0.029 to 0.124). Secondary analyses indicated positive impacts of interventions on several secondary health outcomes. The interventions appeared to be particularly effective for individuals with high attendance during exercise sessions and those with the apolipoprotein E ε4 allele and elevated plasma glial fibrillary acidic protein levels. DISCUSSION: The multidomain intervention showed no efficacy in preventing cognitive decline. Further research on more efficient strategies and suitable target populations is required. Highlights: This trial evaluated the efficacy of multidomain intervention in individuals with MCI. The trial did not show a significant difference in preplanned cognitive outcomes. Interventions had positive effects on a wide range of secondary health outcomes. Those with adequate adherence or high risk of dementia benefited from interventions.

本文言語英語
ページ(範囲)3918-3930
ページ数13
ジャーナルAlzheimer's and Dementia
20
6
DOI
出版ステータス出版済み - 06-2024

All Science Journal Classification (ASJC) codes

  • 疫学
  • 健康政策
  • 発達神経科学
  • 臨床神経学
  • 老年医学
  • 細胞および分子神経科学
  • 精神医学および精神衛生

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