Kestose Increases the Relative Abundance of Faecalibacterium spp. and Nominally Increases Cow Milk Tolerant Dose in Children with Cow's Milk Allergy - Preliminary Results

Shohei Kubota, Shiro Sugiura, Mayuko Takahashi, Yoshihiro Kadota, Yoshihiro Takasato, Teruaki Matsui, Katsumasa Kitamura, Takumi Tochio, Komei Ito

研究成果: ジャーナルへの寄稿学術論文査読

抄録

A single-arm study was conducted with 10 children aged 2-12 years with severe cow's milk allergy (CMA) requiring complete allergen elimination. Subjects were administered kestose, a prebiotic, at 1 or 2 g/day for 12 weeks. Results of a subsequent oral food challenge (OFC) showed a statistically significant increase in the total dose of cow's milk ingestion (1.6 ml vs. 2.7 ml, p = 0.041). However, the overall evaluation of the OFC results, TS/Pro (total score of Anaphylaxis Scoring Aichi (ASCA)/cumulative dose of protein), showed no statistically significant improvement, although the values were nominally improved in seven out of 10 subjects. The 16S rDNA analysis of fecal samples collected from the subjects revealed a statistically significant increase in the proportion of Faecalibacterium spp. (3.8 % vs. 6.8%, p = 0.013), a type of intestinal bacterium that has been reported to be associated with food allergy. However, no statistically significant correlation was found between Faecalibacterium spp. abundance and the results of the OFC.

本文言語英語
ページ(範囲)299-306
ページ数8
ジャーナルPolish Journal of Microbiology
72
3
DOI
出版ステータス出版済み - 09-2023

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 応用微生物学とバイオテクノロジー
  • 微生物学(医療)

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