Kidney transplantation, cardiovascular risk, and long-term dialysis in Japan

M. Tada, M. Hasegawa, H. Sasaki, M. Kusaka, R. Shiroki, K. Hoshinaga, T. Ito, T. Kenmochi, S. Nakai, K. Takahashi, H. Hayashi, S. Koide, Y. Yuzawa

研究成果: Article

1 引用 (Scopus)


Background The waiting time for deceased-donor kidney-only transplantations in Japan is long. Herein, we assessed the effect of length of dialysis on the outcomes of these patients. Methods We divided patients into 2 groups based on length of dialysis (Group A, <15 years, and Group B, ≥15 years), and compared the background and outcomes after kidney transplantation. Results Group A included 210 patients and Group B included 35 patients. In Group B, 20% of transplants were from living donors. Patient age (P =.017) and the hepatitis C infection rate (P =.018) were significantly higher in Group B, whereas hypertension (P =.011), diabetes (P =.041), and ABO-incompatibility rates (P =.015) were significantly higher in Group A. The 5- and 10-year survival rates were 97.0% and 95.4%, respectively, in Group A and 97.1% and 97.1%, respectively, in Group B. The 5- and 10-year graft survival rates were 95.4% and 84.8%, respectively, in Group A and 97.1% and 73.1%, respectively, in Group B. There were no significant differences between the groups in patient survival (P =.74) and graft survival (P =.72). The 5- and 10-year cardiovascular event-free survival rates were 95.9% and 92.4%, respectively, in Group A and 88.6% and 76.8%, respectively, in Group B. Cardiovascular event-free survival was significantly higher in Group A (P =.038). Cox stepwise multivariate analysis indicated that length of dialysis was a significant predictor of cardiovascular events (hazard risk, 1.007; range, 1.001-1.012; P =.012). Conclusion The prognosis after kidney transplantation is promising even after a long length of dialysis, although evaluation of the cardiovascular risk is needed in these cases.

ジャーナルTransplantation Proceedings
出版物ステータスPublished - 01-01-2016


All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation