TY - JOUR
T1 - KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases
AU - Fukaya, S.
AU - Oshima, H.
AU - Kato, K.
AU - Komatsu, Y.
AU - Matsumura, H.
AU - Ishii, K.
AU - Miyama, H.
AU - Nagai, T.
AU - Tanaka, I.
AU - Mizutani, A.
AU - Katayama, M.
AU - Yoshida, S.
AU - Torikai, K.
N1 - Funding Information:
Acknowledgements This work was supported in part by a grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.
PY - 2000
Y1 - 2000
N2 - The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.
AB - The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.
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U2 - 10.1007/s002960000064
DO - 10.1007/s002960000064
M3 - Article
C2 - 11063292
AN - SCOPUS:0033771886
SN - 0172-8172
VL - 19
SP - 223
EP - 225
JO - Rheumatology International
JF - Rheumatology International
IS - 6
ER -