KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases

S. Fukaya, H. Oshima, K. Kato, Y. Komatsu, H. Matsumura, K. Ishii, H. Miyama, T. Nagai, I. Tanaka, A. Mizutani, M. Katayama, S. Yoshida, K. Torikai

研究成果: Article査読

20 被引用数 (Scopus)

抄録

The objective of this study was to determine the role of serum KL-6 levels as a marker for the activity of interstitial pneumonia in patients with connective tissue diseases. The serum concentrations of KL-6, a glycoprotein produced mainly by pulmonary type II epithelial cells, were measured in 21 patients with connective tissue disease. The activity of interstitial pneumonia was compared with the associated serum KL-6 concentrations. Serum KL-6 concentrations in patients with interstitial pneumonia were significantly higher than those in the controls. Among patients with active interstitial pneumonia, serum KL-6 concentrations following the treatment (after improvement) were significantly lower than the pretreatment values. The extent of the pulmonary fibrosis correlated positively with the serum KL-6 concentrations during the inactive phase of the interstitial pneumonia. These results suggest that sequential measurement of serum KL-6 levels is a new and useful means for the evaluation of interstitial pneumonia in patients with connective tissue diseases.

本文言語English
ページ(範囲)223-225
ページ数3
ジャーナルRheumatology International
19
6
DOI
出版ステータスPublished - 2000

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • リウマチ学
  • 免疫学

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