KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

Derek N. Bremmer, Cornelius J. Clancy, Ellen G. Press, Reem Almaghrabi, Liang Chen, E. Yohei Doi, M. Hong Nguyen, Ryan K. Shieldsb

研究成果: Article

13 引用 (Scopus)

抄録

The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.

元の言語English
ページ(範囲)7597-7600
ページ数4
ジャーナルAntimicrobial agents and chemotherapy
58
発行部数12
DOI
出版物ステータスPublished - 01-12-2014
外部発表Yes

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Amikacin
Klebsiella pneumoniae
Carbapenems
Sulfamethoxazole Drug Combination Trimethoprim
Aminoglycosides
Enzymes
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Bremmer, D. N., Clancy, C. J., Press, E. G., Almaghrabi, R., Chen, L., Doi, E. Y., ... Shieldsb, R. K. (2014). KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-. Antimicrobial agents and chemotherapy, 58(12), 7597-7600. https://doi.org/10.1128/AAC.03831-14
Bremmer, Derek N. ; Clancy, Cornelius J. ; Press, Ellen G. ; Almaghrabi, Reem ; Chen, Liang ; Doi, E. Yohei ; Nguyen, M. Hong ; Shieldsb, Ryan K. / KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-. :: Antimicrobial agents and chemotherapy. 2014 ; 巻 58, 番号 12. pp. 7597-7600.
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abstract = "The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30{\%} and 85{\%} of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90{\%} of the strains, indicating that the combination may overcome resistance.",
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Bremmer, DN, Clancy, CJ, Press, EG, Almaghrabi, R, Chen, L, Doi, EY, Nguyen, MH & Shieldsb, RK 2014, 'KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-', Antimicrobial agents and chemotherapy, 巻. 58, 番号 12, pp. 7597-7600. https://doi.org/10.1128/AAC.03831-14

KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-. / Bremmer, Derek N.; Clancy, Cornelius J.; Press, Ellen G.; Almaghrabi, Reem; Chen, Liang; Doi, E. Yohei; Nguyen, M. Hong; Shieldsb, Ryan K.

:: Antimicrobial agents and chemotherapy, 巻 58, 番号 12, 01.12.2014, p. 7597-7600.

研究成果: Article

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AU - Bremmer, Derek N.

AU - Clancy, Cornelius J.

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AU - Almaghrabi, Reem

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AU - Doi, E. Yohei

AU - Nguyen, M. Hong

AU - Shieldsb, Ryan K.

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AB - The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.

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Bremmer DN, Clancy CJ, Press EG, Almaghrabi R, Chen L, Doi EY その他. KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-. Antimicrobial agents and chemotherapy. 2014 12 1;58(12):7597-7600. https://doi.org/10.1128/AAC.03831-14