KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

Derek N. Bremmer, Cornelius J. Clancy, Ellen G. Press, Reem Almaghrabi, Liang Chen, E. Yohei Doi, M. Hong Nguyen, Ryan K. Shieldsb

研究成果: ジャーナルへの寄稿学術論文査読

18 被引用数 (Scopus)

抄録

The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.

本文言語英語
ページ(範囲)7597-7600
ページ数4
ジャーナルAntimicrobial agents and chemotherapy
58
12
DOI
出版ステータス出版済み - 01-12-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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