KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

Derek N. Bremmer; Cornelius J. Clancy; Ellen G. Press; Reem Almaghrabi; Liang Chen; E. Yohei Doi; M. Hong Nguyen; Ryan K. Shieldsb

doi:10.1128/AAC.03831-14

KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-

Derek N. Bremmer, Cornelius J. Clancy, Ellen G. Press, Reem Almaghrabi, Liang Chen, E. Yohei Doi, M. Hong Nguyen, Ryan K. Shieldsb

微生物学

研究成果: Article

13 引用（Scopus）

抜粋

The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.

元の言語	English
ページ（範囲）	7597-7600
ページ数	4
ジャーナル	Antimicrobial agents and chemotherapy
巻	58
発行部数	12
DOI	https://doi.org/10.1128/AAC.03831-14
出版物ステータス	Published - 01-12-2014

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

文献にアクセス

10.1128/AAC.03831-14

フィンガープリント KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

これを引用

Bremmer, D. N., Clancy, C. J., Press, E. G., Almaghrabi, R., Chen, L., Doi, E. Y., Nguyen, M. H., & Shieldsb, R. K. (2014). KPC-Producing klebsiella pneumoniae strains that harbor AAC(6')-. Antimicrobial agents and chemotherapy, 58(12), 7597-7600. https://doi.org/10.1128/AAC.03831-14

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abstract = "The aminoglycoside-modifying enzyme AAC(6')-Ib is common among carbapenem-resistant Klebsiella pneumoniae (CR-Kp) strains. We investigated amikacin (AMK) activity against 20 AAC(6')-Ib-producing CR-Kp strains. MICs clustered at 16 to 32 μg/ml. By the time-kill study, AMK (1× and 4×the MIC) was bactericidal against 30% and 85% of the strains, respectively. At achievable human serum concentrations, however, the majority of strains showed regrowth, suggesting that AAC(6')-Ib confers intermediate AMK resistance. AMK and trimethoprim-sulfamethoxazole (TMP-SMX) were synergistic against 90% of the strains, indicating that the combination may overcome resistance.",

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AU - Bremmer, Derek N.

AU - Clancy, Cornelius J.

AU - Press, Ellen G.

AU - Almaghrabi, Reem

AU - Chen, Liang

AU - Doi, E. Yohei

AU - Nguyen, M. Hong

AU - Shieldsb, Ryan K.

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