Lack of association between orexin receptor gene polymorphisms and obstructive sleep apnea syndrome in Japanese

Wael A. Ahmed, Terumi Mori, Yoichi Nishimura, Seiichi Nakata, Takema Kato, Wam Abdelhamid, Hiroki Kurahashi, Kenji Suzuki

研究成果: Article

抄録

The pathogenesis of obstructive sleep apnea (OSA) is not fully understood, particularly at the genetic level. The orexins have pleiotropic effects on several aspects of the OSA phenotype. The purpose of this study was to investigate the relation between orexin receptor gene polymorphisms and obstructive sleep apnea syndrome (OSAS) in Japanese people. A prospective case-control study was conducted. The study population consisted of one hundred OSAS patients and one hundred control subjects. Nine single-nucleotide polymorphisms (SNPs) in the two orexin receptor genes were genotyped using Applied Biosystems TaqMan SNP Genotyping Assays technology. Both genotypic distribution and allelic frequencies were compared between patients and control subjects. We found that between OSAS patients and control subjects, there were no significant differences in either genotypic distributions or allelic frequencies of the examined SNPs. In conclusion, there are some reports evaluating the plasma level of orexins in patients with OSAS compared to normal subjects. However, the role of orexin genes in the pathogenesis of OSAS has yet to be evaluated. This candidate gene study shows that orexin receptor gene polymorphisms are unlikely to be associated with OSAS in Japanese people.

元の言語English
ページ(範囲)73-77
ページ数5
ジャーナルSleep and Biological Rhythms
9
発行部数2
DOI
出版物ステータスPublished - 01-04-2011

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Orexin Receptors
Obstructive Sleep Apnea
Genes
Single Nucleotide Polymorphism
Case-Control Studies
Technology
Phenotype

All Science Journal Classification (ASJC) codes

  • Physiology
  • Neuropsychology and Physiological Psychology
  • Neurology
  • Physiology (medical)

これを引用

Ahmed, Wael A. ; Mori, Terumi ; Nishimura, Yoichi ; Nakata, Seiichi ; Kato, Takema ; Abdelhamid, Wam ; Kurahashi, Hiroki ; Suzuki, Kenji. / Lack of association between orexin receptor gene polymorphisms and obstructive sleep apnea syndrome in Japanese. :: Sleep and Biological Rhythms. 2011 ; 巻 9, 番号 2. pp. 73-77.
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Lack of association between orexin receptor gene polymorphisms and obstructive sleep apnea syndrome in Japanese. / Ahmed, Wael A.; Mori, Terumi; Nishimura, Yoichi; Nakata, Seiichi; Kato, Takema; Abdelhamid, Wam; Kurahashi, Hiroki; Suzuki, Kenji.

:: Sleep and Biological Rhythms, 巻 9, 番号 2, 01.04.2011, p. 73-77.

研究成果: Article

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