Lack of association between prokineticin 2 gene and Japanese methamphetamine dependence

Taro Kishi, Tsuyoshi Kitajima, Tomoko Tsunoka, Takenori Okumura, Kunihiro Kawashima, Tomo Okochi, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Disruption of circadian rhythms may be involved in the pathophysiology of psychiatric disorders, including drug addiction. Recently, we detected the significant association between prokineticin 2 receptor gene (PROKR2) and Japanese methamphetamine dependence patients. Also, prokineticin 2 (PK2) gene deficient mice showed reduced physiological and behavioral parameters, including circadian locomotor activity, circulating glucocorticoid, glucose levels and the expression of peripheral clock genes compared with WT mice. These evidences indicate that PK2 gene (PROK2) is a good candidate gene for the pathogenesis of methamphetamine dependence. To evaluate the association between PROK2 and methamphetamine dependence, we conducted a case-control study of Japanese samples (215 methamphetamine dependence and 232 controls) with four tagging SNPs selected by HapMap database. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients. Written informed consent was obtained from each subject. This study was approved by the ethics committees at Fujita Health University, Nagoya University Graduate School of Medicine and each participating member of the Institute of the Japanese Genetics Initiative for Drug Abuse (JGIDA). We did not detect an association between PROK2 and Japanese methamphetamine dependence patients in allele/genotype-wise analysis, or the haplotype analysis. Our findings suggest that PROK2 does not play a major role in the pathophysiology of methamphetamine dependence in the Japanese population.

本文言語English
ページ(範囲)133-136
ページ数4
ジャーナルCurrent Neuropharmacology
9
1
DOI
出版ステータスPublished - 2011

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 薬理学(医学)

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