Lateral hypothalamic circuits for sleep–wake control

Takayuki Yamashita, Akihiro Yamanaka

研究成果: Review article査読

33 被引用数 (Scopus)

抄録

The lateral hypothalamic area (LHA) of the diencephalon is crucially involved in controlling instinctive behavior such as sleep–wake cycle and feeding behavior. LHA is a heterogeneous structure that contains spatially intermingled, genetically distinct cell populations. Among LHA neurons, orexin/hypocretin (OX) neuron is the key cell type that promotes waking, and specific loss of OX neurons results in narcolepsy. Melanin-concentrating hormone (MCH) containing neurons are known to be active during rapid eye movement (REM) sleep and stimulation of these neurons promotes REM sleep. Here we review the classical and more recent findings in this field and discuss the molecular and cellular network organization of LHA neurons that could ultimately regulate the switch between wakefulness and general states of sleep.

本文言語English
ページ(範囲)94-100
ページ数7
ジャーナルCurrent Opinion in Neurobiology
44
DOI
出版ステータスPublished - 01-06-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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