Learning and memory in two different reward tasks in a radial arm maze in rats

Jue He, Kiyofumi Yamada, Akira Nakajima, Hiroyuki Kamei, Toshitaka Nabeshima

研究成果: Article

23 引用 (Scopus)

抜粋

In an eight-arm radial maze, working and reference memory can be assessed simultaneously in the fixed position of reward task (FPRT) in which half of the arms are baited and their positions are fixed throughout the training trails. We characterized performance of rats in the variable position of reward task (VPRT), in which four out of eight arms were baited, but the positions were varied in every training trial. In the VPRT, the rats learned to choose all arms without any discrimination between baited and non-baited arms and the memory retention was time-dependent. The performance of rats in the FPRT was impaired by altering the spatial organization of the extramaze cues while it was not affected in the VPRT. The number of Fos-positive cells transiently increased in the cerebral cortex and hippocampus of both groups of animals during the training. Finally, bilateral lesions of the dorsal hippocampus resulted in an impairment of working memory in the FPRT and the performance of the rats in the VPRT. These results suggest that different strategies are used between the FPRT and VPRT but the hippocampus plays an important role in performance of rats trained for the VPRT as well as FPRT.

元の言語English
ページ(範囲)139-148
ページ数10
ジャーナルBehavioural Brain Research
134
発行部数1-2
DOI
出版物ステータスPublished - 21-08-2002
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

これを引用