Linkage disequilibrium and association with methamphetamine dependence/psychosis of μ-opioid receptor gene polymorphisms

S. Ide, H. Kobayashi, H. Ujike, N. Ozaki, Y. Sekine, T. Inada, M. Harano, T. Komiyama, M. Yamada, M. Iyo, N. Iwata, K. Tanaka, H. Shen, K. Iwahashi, M. Itokawa, M. Minami, M. Satoh, K. Ikeda, Ide Sora

研究成果: Article査読

37 被引用数 (Scopus)

抄録

Several studies indicate that the μ-opioid receptor plays a role in addiction not only to opiate drugs but also to alcohol and non-opiate addictive drugs. Our studies aim to reveal the associations between gene polymorphisms and methamphetamine (MAP) dependence/psychosis. We newly identified several polymorphisms and four substantial linkage disequilibrium (LD) blocks in the μ-opioid receptor (OPRM1) gene. We found significant differences in both genotype and allele frequencies of the single-nucleotide polymorphism (SNP) IVS2 + G691C between control (n=232) and MAP-dependent/psychotic patients (n=128). There was also a significant association between IVS2 + G691C and patients with transient psychosis. These results suggest that the OPRM1 gene variations may be a factor in development and prognosis of MAP psychosis.

本文言語English
ページ(範囲)179-188
ページ数10
ジャーナルPharmacogenomics Journal
6
3
DOI
出版ステータスPublished - 05-2006

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 遺伝学
  • 薬理学

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