TY - JOUR
T1 - Lipase member H frequently overexpressed in human esophageal adenocarcinomas
AU - Ishimine, Hisako
AU - Zhou, Rui
AU - Sumitomo, Kenya
AU - Ito, Yoshimasa
AU - Seki, Yasuhiro
AU - Yoshida, Yukihiro
AU - Kurisaki, Akira
N1 - Funding Information:
The esophageal adenocarcinoma cell line (KYAE-1) was obtained from JCRB Cell Bank. SK-GT-2 and SK-GT-4 cell lines were obtained from the Public Health England. Dr. Rui Zhou is supported as an International Research Fellow of the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2015, International Society of Oncology and BioMarkers (ISOBM).
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Esophageal cancer is one of the most frequent causes of cancer-related deaths worldwide. This is due to its asymptomatic nature or mild nonspecific symptoms. Most patients are diagnosed after appearance of prominent symptoms, and tumors are frequently accompanied by severe infiltration. Therefore, molecular biomarkers for the prognosis of early-stage esophageal cancer are desired. In this study, we examined the prognostic potential of lipase H (LIPH), a recently reported biomarker for lung adenocarcinoma and squamous carcinoma. We found that LIPH mRNA is also frequently upregulated in esophageal adenocarcinoma. Immunohistochemical analysis confirmed LIPH protein expression in various esophageal tumor tissue sections. Interestingly, higher expression of LIPH in esophageal adenocarcinoma showed a positive correlation with longer survival of patients. Our data suggest that LIPH may have prognostic value for esophageal cancer.
AB - Esophageal cancer is one of the most frequent causes of cancer-related deaths worldwide. This is due to its asymptomatic nature or mild nonspecific symptoms. Most patients are diagnosed after appearance of prominent symptoms, and tumors are frequently accompanied by severe infiltration. Therefore, molecular biomarkers for the prognosis of early-stage esophageal cancer are desired. In this study, we examined the prognostic potential of lipase H (LIPH), a recently reported biomarker for lung adenocarcinoma and squamous carcinoma. We found that LIPH mRNA is also frequently upregulated in esophageal adenocarcinoma. Immunohistochemical analysis confirmed LIPH protein expression in various esophageal tumor tissue sections. Interestingly, higher expression of LIPH in esophageal adenocarcinoma showed a positive correlation with longer survival of patients. Our data suggest that LIPH may have prognostic value for esophageal cancer.
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U2 - 10.1007/s13277-015-3985-y
DO - 10.1007/s13277-015-3985-y
M3 - Article
C2 - 26341494
AN - SCOPUS:84940825378
SN - 1010-4283
VL - 37
SP - 2075
EP - 2081
JO - Oncodevelopmental Biology and Medicine
JF - Oncodevelopmental Biology and Medicine
IS - 2
ER -