Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder

Takuya Masui, Ryota Hashimoto, Ichiro Kusumi, Katsuji Suzuki, Teruaki Tanaka, Shin Nakagawa, Tatsuyo Suzuki, Nakao Iwata, Norio Ozaki, Tadafumi Kato, Hiroshi Kunugi, Tsukasa Koyama

研究成果: Article査読

43 被引用数 (Scopus)

抄録

Lithium is a first-line agent for the treatment of bipolar disorder. A significant association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder has been reported. We investigated whether this polymorphism is associated with the response to lithium treatment in Japanese patients with bipolar disorder. Patients had been treated with lithium carbonate for more than 1 year, and the response was retrospectively evaluated. No significant differences were found in the genotype distribution or allele frequency between responders and non-responders. Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder.

本文言語English
ページ(範囲)49-50
ページ数2
ジャーナルPsychiatric Genetics
16
2
DOI
出版ステータスPublished - 04-2006

All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 遺伝学(臨床)
  • 精神医学および精神衛生
  • 生物学的精神医学

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