Living donor pancreas transplantation in Japan

Takashi Kenmochi, Takehide Asano, Michihiro Maruyama, Kenichi Saigo, Naotake Akutsu, Chikara Iwashita, Kazunori Ohtsuki, Akiko Suzuki, Mariko Miyazaki

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Background/purpose Living-donor pancreas transplants (LDPs) were introduced at Chiba-East National Hospital in 2004, and 12 LDPs have been performed at this institution to date. Based on the outcome of these 12 LDPs, the efficacy and safety of LDPs are herein discussed. Methods Twelve diabetic patients underwent LDPs; ten had simultaneous pancreas and kidney transplants from living donors, one had pancreas transplant after a kidney transplant from a living donor, and one had a pancreas transplant alone from a living donor. The donors were parents or brothers and the ABO blood types were incompatible in three LDPs. The procedures for the donor and recipient operations were performed according to the technique established by the University of Minnesota. Bladder drainage was used in 11 recipients and enteric drainage was used in one patient. Tacrolimus, basiliximab, mycophenolate mofetil, and prednisone were used for induction and immunosuppressive treatment. A splenectomy, double-filtered plasmapheresis, and plasma exchange were added in the ABO-incompatible LDPs. Results No complications were observed in the donors during hospitalization. The 1-year survivals of the patients, kidney grafts, and pancreas grafts were 100, 100, and 100%, respectively. The 3-year survivals were 91.7, 90, and 91.7%, respectively. Three patients developed leakage of pancreatic juice and one patient required a surgical procedure. Cytomegalovirus antigenemia was detected in five patients (42%). Conclusions Based on the excellent outcome of the LDPs at this institution, LDPs is therefore expected to become a promising option for the treatment of patients with severe diabetes.

本文言語English
ページ(範囲)101-107
ページ数7
ジャーナルJournal of Hepato-Biliary-Pancreatic Sciences
17
2
DOI
出版ステータスPublished - 03-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

フィンガープリント 「Living donor pancreas transplantation in Japan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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