Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression

Hironori Nishitsuji, Saneyuki Ujino, Sachiyo Yoshio, Masaya Sugiyama, Masashi Mizokami, Tatsuya Kanto, Kunitada Shimotohno

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.

本文言語English
ページ(範囲)10388-10393
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
113
37
DOI
出版ステータスPublished - 13-09-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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