Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: A 2-year follow-up study

Hajime Haimoto, Mitsunaga Iwata, Kenji Wakai, Hiroyuki Umegaki

研究成果: Article

34 引用 (Scopus)

抄録

The aim was to assess the long-term effect of a loose restriction of carbohydrate intake (carbohydrate-reduced diet: CARD) compared to a conventional diet (CD) in type 2 diabetes. One hundred and thirty-three type 2 diabetic outpatients followed the CD (n = 57, 1734 ± 410 kcal, carbohydrate:protein:fat ratio = 57:16:26) or CARD (n = 76, 1773 ± 441 kcal, carbohydrate:protein:fat ratio = 45:18:33) according to their own will, and were followed up for 2 years. Glycemic control, body mass index (BMI), serum cholesterols and dose of antidiabetic drugs were assessed at baseline and after 1 and 2 years. At baseline, hemoglobin A1c (HbA1c) and BMI levels were 7.1 ± 1.0% and 24.2 ± 2.9, respectively, in the CD group, and 7.4 ± 1.1% and 25.1 ± 3.4 in the CARD group, showing no significant differences. During the 2-year follow-up period, HbA1c levels were significantly improved in the CARD group (CD: 7.5 ± 1.3%, CARD: 6.7 ± 0.6%, P < 0.001), and BMI decreased more significantly in the CARD group (CD: 23.8 ± 3.0, CARD: 23.8 ± 3.5, P < 0.001). The doses of sulfonylureas clearly tapered, and serum cholesterol profiles improved significantly with the CARD. Our results warrant a long-term and large-scale randomized study of the diet for type 2 diabetes.

元の言語English
ページ(範囲)350-356
ページ数7
ジャーナルDiabetes Research and Clinical Practice
79
発行部数2
DOI
出版物ステータスPublished - 01-02-2008

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varespladib methyl
Type 2 Diabetes Mellitus
Hemoglobins
Body Mass Index
Carbohydrates
Diet
Fats
Cholesterol
Serum
Hypoglycemic Agents
Proteins
Outpatients

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

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title = "Long-term effects of a diet loosely restricting carbohydrates on HbA1c levels, BMI and tapering of sulfonylureas in type 2 diabetes: A 2-year follow-up study",
abstract = "The aim was to assess the long-term effect of a loose restriction of carbohydrate intake (carbohydrate-reduced diet: CARD) compared to a conventional diet (CD) in type 2 diabetes. One hundred and thirty-three type 2 diabetic outpatients followed the CD (n = 57, 1734 ± 410 kcal, carbohydrate:protein:fat ratio = 57:16:26) or CARD (n = 76, 1773 ± 441 kcal, carbohydrate:protein:fat ratio = 45:18:33) according to their own will, and were followed up for 2 years. Glycemic control, body mass index (BMI), serum cholesterols and dose of antidiabetic drugs were assessed at baseline and after 1 and 2 years. At baseline, hemoglobin A1c (HbA1c) and BMI levels were 7.1 ± 1.0{\%} and 24.2 ± 2.9, respectively, in the CD group, and 7.4 ± 1.1{\%} and 25.1 ± 3.4 in the CARD group, showing no significant differences. During the 2-year follow-up period, HbA1c levels were significantly improved in the CARD group (CD: 7.5 ± 1.3{\%}, CARD: 6.7 ± 0.6{\%}, P < 0.001), and BMI decreased more significantly in the CARD group (CD: 23.8 ± 3.0, CARD: 23.8 ± 3.5, P < 0.001). The doses of sulfonylureas clearly tapered, and serum cholesterol profiles improved significantly with the CARD. Our results warrant a long-term and large-scale randomized study of the diet for type 2 diabetes.",
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AU - Iwata, Mitsunaga

AU - Wakai, Kenji

AU - Umegaki, Hiroyuki

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N2 - The aim was to assess the long-term effect of a loose restriction of carbohydrate intake (carbohydrate-reduced diet: CARD) compared to a conventional diet (CD) in type 2 diabetes. One hundred and thirty-three type 2 diabetic outpatients followed the CD (n = 57, 1734 ± 410 kcal, carbohydrate:protein:fat ratio = 57:16:26) or CARD (n = 76, 1773 ± 441 kcal, carbohydrate:protein:fat ratio = 45:18:33) according to their own will, and were followed up for 2 years. Glycemic control, body mass index (BMI), serum cholesterols and dose of antidiabetic drugs were assessed at baseline and after 1 and 2 years. At baseline, hemoglobin A1c (HbA1c) and BMI levels were 7.1 ± 1.0% and 24.2 ± 2.9, respectively, in the CD group, and 7.4 ± 1.1% and 25.1 ± 3.4 in the CARD group, showing no significant differences. During the 2-year follow-up period, HbA1c levels were significantly improved in the CARD group (CD: 7.5 ± 1.3%, CARD: 6.7 ± 0.6%, P < 0.001), and BMI decreased more significantly in the CARD group (CD: 23.8 ± 3.0, CARD: 23.8 ± 3.5, P < 0.001). The doses of sulfonylureas clearly tapered, and serum cholesterol profiles improved significantly with the CARD. Our results warrant a long-term and large-scale randomized study of the diet for type 2 diabetes.

AB - The aim was to assess the long-term effect of a loose restriction of carbohydrate intake (carbohydrate-reduced diet: CARD) compared to a conventional diet (CD) in type 2 diabetes. One hundred and thirty-three type 2 diabetic outpatients followed the CD (n = 57, 1734 ± 410 kcal, carbohydrate:protein:fat ratio = 57:16:26) or CARD (n = 76, 1773 ± 441 kcal, carbohydrate:protein:fat ratio = 45:18:33) according to their own will, and were followed up for 2 years. Glycemic control, body mass index (BMI), serum cholesterols and dose of antidiabetic drugs were assessed at baseline and after 1 and 2 years. At baseline, hemoglobin A1c (HbA1c) and BMI levels were 7.1 ± 1.0% and 24.2 ± 2.9, respectively, in the CD group, and 7.4 ± 1.1% and 25.1 ± 3.4 in the CARD group, showing no significant differences. During the 2-year follow-up period, HbA1c levels were significantly improved in the CARD group (CD: 7.5 ± 1.3%, CARD: 6.7 ± 0.6%, P < 0.001), and BMI decreased more significantly in the CARD group (CD: 23.8 ± 3.0, CARD: 23.8 ± 3.5, P < 0.001). The doses of sulfonylureas clearly tapered, and serum cholesterol profiles improved significantly with the CARD. Our results warrant a long-term and large-scale randomized study of the diet for type 2 diabetes.

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