Long-term in vivo left ventricular assist device study for 284 days with Gyro PI pump

Goro Ohtsuka, Kin ichi Nakata, Masaharu Yoshikawa, Tamaki Takano, Julia Glueck, Yoshiyuki Sankai, Yoshiyuki Takami, Juergen Mueller, Akinori Sueoka, George Letsou, Heinrich Schima, Helmut Schmallegger, Ernst Wolner, Hitoshi Koyanagi, Akira Fujisawa, John C. Baldwin, Yukihiko Nosé

研究成果: Article査読

16 被引用数 (Scopus)

抄録

A totally implantable centrifugal artificial heart has been developed. The plastic prototype, the Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart (TAH), 2 week screening tests for antithrombogenecity, and a 1 month system feasibility study. Based upon these results, a metallic prototype, the Gyro PI 700 series, was subjected to long- term in vivo left ventricular assist device (LVAD) studies of over 1 month. The Gyro PI 700 series has the same inner dimension and same characteristics of the Gyro PI 601 such as an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI metallic pump is also driven with the Vienna DC brushless motor actuator like the PI 601. The pump- actuator package was implanted in 3 calves in the preperitoneal space, bypassing from the left ventricular (LV) apex to the descending aorta. Case 1 achieved a 284 day survival. Case 2 was euthanized early at 72 postoperative days as a result of the functional obstruction of the inlet port due to the excessive growth of the calf. There was no blood clot inside the pumps of either case. Case 3 is on-going (22 days on July 24, 1998). During these periods, all cases showed no physiological abnormalities. In conclusion, the PI 700 series pump has excellent results as a long-term implantable LVAD.

本文言語English
ページ(範囲)504-507
ページ数4
ジャーナルArtificial Organs
23
6
DOI
出版ステータスPublished - 05-07-1999
外部発表はい

All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 医学(その他)
  • 生体材料
  • 生体医工学

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