Long-term in vivo left ventricular assist device study with a titanium centrifugal pump

Goro Ohtsuka, Kin Ichi Nakata, Masaharu Yoshikawa, Juergen Mueller, Tamaki Takano, Shingo Yamane, Nicole Gronau, Julia Glueck, Yoshiyuki Takami, Akinori Sueoka, George Letsou, Heinrich Schima, Helmut Schmallegger, Ernst Wolner, Hitoshi Koyanagi, Akira Fujisawa, John C. Baldwin, Yukihiko Nosé

研究成果: Article査読

14 被引用数 (Scopus)

抄録

A totally implantable centrifugal artificial heart has been developed. The plastic prototype, Gyro PI 601, passed 2 day hemodynamic tests as a functional total artificial heart, 2 week screening tests for antithrombogenicity, and 1 month system feasibility. Based on these results, a metallic prototype, Gyro PI 702, was subjected to in vivo left ventricular assist device (LVAD) studies. The pump system employed the Gyro PI 702, which has the same inner dimensions and the same characteristics as the Gyro PI 601, including an eccentric inlet port, a double pivot bearing system, and a magnet coupling system. The PI 702 is driven with the Vienna DC brushless motor actuator. For the in vivo LVAD study, the pump actuator package was implanted in the preperitoneal space in two calves, from the left ventricular apex to the descending aorta. Case 1 achieved greater than 9 month survival without any complications, at an average flow rate of 6.6 L/min with 10.2 W input power. Case 2 was killed early due to the excessive growth of the calf, which caused functional obstruction of the inlet port. There was no blood clot inside the pump. During these periods, neither case exhibited any physiologic abnormalities. The PI 702 pump gives excellent results as a long-term implantable LVAD.

本文言語English
ページ(範囲)M619-M623
ジャーナルASAIO Journal
44
5
DOI
出版ステータスPublished - 01-01-1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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