抄録
We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions of surrounding muscles. Treadmill walking was monitored and the animals showed no functional deficits as a result of implantation. In a different set of experiments, electrodes with lead wires were implanted for up to 7 mo and the animals were tested at 2-4 week intervals at which time stimulation thresholds and recorded sensory activity were monitored for every electrode. It was shown that surgical technique highly affected the long-term stimulation results. Results between measurement sessions were compared, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days). The recorded sensory signals, however, were not stable over time. A histological analysis performed on all implanted tissues indicated that the morphology and fiber density of the nerve around the electrodes were normal.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 146-157 |
| ページ数 | 12 |
| ジャーナル | IEEE Transactions on Biomedical Engineering |
| 巻 | 51 |
| 発行部数 | 1 |
| DOI | |
| 出版物ステータス | Published - 01-01-2004 |
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All Science Journal Classification (ASJC) codes
- Biomedical Engineering
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Long-Term Stimulation and Recording with a Penetrating Microelectrode Array in Cat Sciatic Nerve. / Branner, Almut; Stein, Richard B.; Fernandez, Eduardo; Aoyagi, Yoichiro; Normann, Richard A.
：: IEEE Transactions on Biomedical Engineering, 巻 51, 番号 1, 01.01.2004, p. 146-157.研究成果: Article
TY - JOUR
T1 - Long-Term Stimulation and Recording with a Penetrating Microelectrode Array in Cat Sciatic Nerve
AU - Branner, Almut
AU - Stein, Richard B.
AU - Fernandez, Eduardo
AU - Aoyagi, Yoichiro
AU - Normann, Richard A.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions of surrounding muscles. Treadmill walking was monitored and the animals showed no functional deficits as a result of implantation. In a different set of experiments, electrodes with lead wires were implanted for up to 7 mo and the animals were tested at 2-4 week intervals at which time stimulation thresholds and recorded sensory activity were monitored for every electrode. It was shown that surgical technique highly affected the long-term stimulation results. Results between measurement sessions were compared, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days). The recorded sensory signals, however, were not stable over time. A histological analysis performed on all implanted tissues indicated that the morphology and fiber density of the nerve around the electrodes were normal.
AB - We studied the consequences of long-term implantation of a penetrating microelectrode array in peripheral nerve over the time course of 4-6 mo. Electrode arrays without lead wires were implanted to test the ability of different containment systems to protect the array and nerve during contractions of surrounding muscles. Treadmill walking was monitored and the animals showed no functional deficits as a result of implantation. In a different set of experiments, electrodes with lead wires were implanted for up to 7 mo and the animals were tested at 2-4 week intervals at which time stimulation thresholds and recorded sensory activity were monitored for every electrode. It was shown that surgical technique highly affected the long-term stimulation results. Results between measurement sessions were compared, and in the best case, the stimulation properties stabilized in 80% of the electrodes over the course of the experiment (162 days). The recorded sensory signals, however, were not stable over time. A histological analysis performed on all implanted tissues indicated that the morphology and fiber density of the nerve around the electrodes were normal.
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UR - http://www.scopus.com/inward/citedby.url?scp=0348147669&partnerID=8YFLogxK
U2 - 10.1109/TBME.2003.820321
DO - 10.1109/TBME.2003.820321
M3 - Article
C2 - 14723504
AN - SCOPUS:0348147669
VL - 51
SP - 146
EP - 157
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
SN - 0018-9294
IS - 1
ER -