Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis

Mitsuo Goto, Tetsuya Tsukamoto, Ken Ichi Inada, Tsutomu Mizoshita, Tetsuya Ogawa, Akihiro Terada, Ikuo Hyodo, Kazuo Shimozato, Yasuhisa Hasegawa, Masae Tatematsu

研究成果: Article査読

21 被引用数 (Scopus)

抄録

The clinicopathological significance of cell-cycle proteins has remained unclear in oral tongue squamous cell carcinomas (OTSCC). In the current study, we evaluated several cell-cycle proteins in relation to clinicopathological parameters and disease outcome for OTSCC. A total of 123 previously untreated patients with OTSCC, who underwent surgical treatment, were enrolled. Tumor specimens were examined for expression of p21, p27, p16, p53, and p63 using immunohistochemistry, with reference to clinicopathological factors and disease outcome. It is noteworthy that differences in p21 immunoreactivity were evident between the shallow region and invasive front of tumors within the same specimens. Loss of p21 expression in invasive fronts was found to be associated with clinicopathological factors of tumor progression and poor prognosis. p21 expression in invasive fronts is a significant indicator for impact on survival. Moreover, p21 is one of the important factors that regulate the progression of malignant cells in OTSCC.

本文言語English
ページ(範囲)837-846
ページ数10
ジャーナルOncology reports
14
4
DOI
出版ステータスPublished - 10-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント 「Loss of p21<sup>WAF1/CIP1</sup> expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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