Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival

Hirozumi Sawai, Akira Yasuda, Nobuo Ochi, Jiachi Ma, Yoichi Matsuo, Takehiro Wakasugi, Hiroki Takahashi, Hitoshi Funahashi, Mikinori Sato, Hiromitsu Takeyama

研究成果: Article査読

110 被引用数 (Scopus)

抄録

Background: The tumour suppressor phosphatase and tensin homolog (PTEN) is an important negative regulator of cell-survival signaling. To evaluate the correlation between PTEN expression and clinicopathological characteristics of colorectal cancer patients with and without liver metastases, we investigated PTEN expression in primary colorectal cancer and colorectal cancer liver metastases. Methods: Sixty-nine pairs of primary colorectal cancer and corresponding liver metastasis specimens were analyzed immunohistochemically, and the correlation between immunohistochemical findings and clinicopathological factors was investigated. Seventy primary colorectal cancer specimens from patients without liver metastases were used as controls. Results: PTEN was strongly expressed in 44 (62.9%) colorectal cancer specimens from patients without liver metastases. In contrast, PTEN was weakly expressed in 52 (75.4%) primary colorectal cancer specimens from patients with liver metastases, and was absent in liver metastases. Weak PTEN expression in colorectal cancer tissues was significantly associated with advanced TNM stage (p < 0.01) and lymph node metastasis (p < 0.05). PTEN expression was significantly stronger in primary colorectal cancer specimens from patients without liver metastases. Furthermore, among colorectal cancer patients with liver metastases, the 5-year survival rate was significantly higher in patients with positive PTEN expression compared to those with negative PTEN expression (p = 0.012). Conclusion: Our results suggest that loss of PTEN expression is involved with colorectal cancer aggressive capacity and that diagnostic evaluation of PTEN expression may provide valuable prognostic information to aid treatment strategies for colorectal cancer patients.

本文言語English
論文番号56
ジャーナルBMC gastroenterology
8
DOI
出版ステータスPublished - 26-11-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 消化器病学

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