Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult

Koji Tamakoshi, Hiroshi Yatsuya, Keiko Wada, Kunihiro Matsushita, Rei Otsuka, Kaichiro Sugiura, Takaaki Kondo, Hideaki Toyoshima

研究成果: Article

12 引用 (Scopus)

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Purpose: Low birth weight has been associated with metabolic and vascular diseases, but the precise mechanism is debated. Adiponectin is one of the key molecules in metabolic disease, and a decrease in level precedes the onset of type 2 diabetes and development of atherosclerosis. Our aim is to examine whether low birth weight is associated with adiponectin concentration in adult. Methods: We conducted a population-based cross-sectional study of 2277 subjects (1661 men and 616 women) aged 35 to 66 years who had their self-reported birth weights and adiponectin concentrations measured as adults. Results: After adjusting for potential confounders, including age, sex, current body mass index (BMI), smoking status, alcohol consumption, and exercise, geometric mean adiponectin levels were 6.63, 6.45, 6.86, 7.05, 6.75, and 7.22 μg/mL for subjects with birth weights less than 2500, 2500 to less than 2800, 2800 to less than 3000, 3000 to less than 3200, 3200 to less than 3500, and greater than 3500 g, respectively. A positive association was found between birth weight and adiponectin concentration (trend p = 0.002). Stratified by current BMI of 25 kg/m2, a positive association was not observed for subjects with a BMI less than 25 kg/m2, but was pronounced in those with a BMI of 25 kg/m2 or greater. Conclusion: This study indicates that low birth weight contributes to decreased adiponectin concentrations in adult life independently of current BMI, especially for obese subjects.

元の言語English
ページ(範囲)669-674
ページ数6
ジャーナルAnnals of Epidemiology
16
発行部数9
DOI
出版物ステータスPublished - 01-09-2006
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Epidemiology

これを引用

Tamakoshi, K., Yatsuya, H., Wada, K., Matsushita, K., Otsuka, R., Sugiura, K., Kondo, T., & Toyoshima, H. (2006). Low Birth Weight Is Associated With Reduced Adiponectin Concentration in Adult. Annals of Epidemiology, 16(9), 669-674. https://doi.org/10.1016/j.annepidem.2006.01.005