Low Frequency of Rearrangements of the ret and trk Proto‐oncogenes in Japanese Thyroid Papillary Carcinomas

Worawidh Wajjwalku, Shigeo Nakamura, Yasuhisa Hasegawa, Koichi Miyazaki, Yasuyuki Satoh, Hiroomi Funahashi, Mutsushi Matsuyama, Masahide Takahashi

研究成果: Article査読

103 被引用数 (Scopus)

抄録

We investigated the frequency of rearrangements of the ret and trk proto‐oncogenes in Japanese thyroid tumors. DNAs from 38 thyroid papillary carcinomas and 14 follicular adenomas were analyzed by Southern blotting. Rearrangements of the ret and trk proto‐oncogenes were detected in one and two papillary carcinomas, respectively, but not in follicular adenomas. Analysis by a reverse transcriptase‐polymerase chain reaction method showed that the ret rearrangement‐positive tumor contained the PTC/refTPCchimeric transcript, which was reported to be found specifically in thyroid tumors and adenomatous goiter. We also found that rearranged mRNA of the trk proto‐oncogene was expressed at high levels in one of two trk rearrangement‐positive tumors. Our results indicated that the frequency of rearrangements of these proto‐oncogenes in Japanese papillary carcinomas was much lower than that in Italian patients.

本文言語English
ページ(範囲)671-675
ページ数5
ジャーナルJapanese Journal of Cancer Research
83
7
DOI
出版ステータスPublished - 07-1992
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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