TY - JOUR
T1 - Low leptin but high insulin resistance of smokers in Japanese men
AU - Hotta, Yo
AU - Yatsuya, Hiroshi
AU - Toyoshima, Hideaki
AU - Matsushita, Kunihiro
AU - Mitsuhashi, Hirotsugu
AU - Takefuji, Seiko
AU - Oiso, Yutaka
AU - Tamakoshi, Koji
N1 - Funding Information:
The authors wish to express their sincere appreciation to the participants, and to the healthcare personnel of the local government office. This work was supported by grants to Hiroshi Yatsuya (17790384), Koji Tamakoshi (18590594), and Hideaki Toyoshima (17390185) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Japan Atherosclerosis Prevention Fund (JAPF), and the Nagoya Preventive Medical Institute.
PY - 2008/9
Y1 - 2008/9
N2 - Aims: To investigate the association between smoking and leptin, and to discuss their influence on diabetes in a large-scale study of Japanese men. Methods: A cross-sectional study was carried out in 2002. The subjects were 2836 men aged 35-66. Smoking history was investigated in a self-administered questionnaire. Blood leptin, glucose and insulin were measured. Results: Significant differences in leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR) related to smoking status were observed (P = 0.001 and P = 0.008, respectively). The multivariate-adjusted geometric means of leptin in current, past and never smokers were 3.88, 4.08 and 4.12 ng/ml, respectively, while the means of HOMA-IR were 1.64, 1.61 and 1.49, respectively. The age-, body mass index-, and other lifestyle-adjusted prevalences of diabetes in current and never smokers were 9.2 and 4.7%, respectively. That of current smokers was significantly higher than in never smokers (P < 0.001). The dose-dependent association found between the intensity of smoking and leptin levels in current smokers was statistically significant (P = 0.030). Conclusions: The present finding may explain in part an association among smoking, leptin levels and diabetes. Smoking is one of the important modifiable risk factors for the prevention of diabetes.
AB - Aims: To investigate the association between smoking and leptin, and to discuss their influence on diabetes in a large-scale study of Japanese men. Methods: A cross-sectional study was carried out in 2002. The subjects were 2836 men aged 35-66. Smoking history was investigated in a self-administered questionnaire. Blood leptin, glucose and insulin were measured. Results: Significant differences in leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR) related to smoking status were observed (P = 0.001 and P = 0.008, respectively). The multivariate-adjusted geometric means of leptin in current, past and never smokers were 3.88, 4.08 and 4.12 ng/ml, respectively, while the means of HOMA-IR were 1.64, 1.61 and 1.49, respectively. The age-, body mass index-, and other lifestyle-adjusted prevalences of diabetes in current and never smokers were 9.2 and 4.7%, respectively. That of current smokers was significantly higher than in never smokers (P < 0.001). The dose-dependent association found between the intensity of smoking and leptin levels in current smokers was statistically significant (P = 0.030). Conclusions: The present finding may explain in part an association among smoking, leptin levels and diabetes. Smoking is one of the important modifiable risk factors for the prevention of diabetes.
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U2 - 10.1016/j.diabres.2008.05.005
DO - 10.1016/j.diabres.2008.05.005
M3 - Article
C2 - 18579252
AN - SCOPUS:48949086573
SN - 0168-8227
VL - 81
SP - 358
EP - 364
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -
