Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity

Tomohiro Mizuno, Takahiro Hayashi, Yuka Shimabukuro, Maho Murase, Hiroki Hayashi, Kazuhiro Ishikawa, Kazuo Takahashi, Yukio Yuzawa, Shigeki Yamada, Tadashi Nagamatsu

研究成果: Article

2 引用 (Scopus)

抄録

Background and Aims: Cisplatin-induced nephrotoxicity primarily occurs in the proximal tubules, and tubular injuries reduce glomerular filtration rates. Lower blood pressure causes renal hypoperfusion, which promotes ischemic acute kidney injury (AKI). Our study examined the relationship between lower blood pressure-induced renal hypoperfusion and cisplatin-induced nephrotoxicity. Methods: The relationship between cisplatin use and hypoalbuminemia is not clear. This study consisted of Japanese patients who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital from April 2006 to December 2012. Hypoalbuminemia was defined as serum albumin levels ≤3.5 mg/dl. Results: Patients who experienced lower blood pressure during chemotherapy were included in the lower blood pressure group (n = 229), and those who did not were included in the normal blood pressure group (n = 743). Total cisplatin dose in the normal blood pressure and lower blood pressure groups was 58.9 ± 23.8 and 55.0 ± 20.4 mg/m 2 , respectively. The rate of severe nephrotoxicity was higher and overall survival was shorter in the lower blood pressure group than in the normal blood pressure group. In a multivariable analysis, lower blood pressure significantly correlated with hypoalbuminemia. Conclusions: To prevent ischemic AKI, nutrition and cachexia controlling are important parts of cancer treatment.

元の言語English
ページ(範囲)313-320
ページ数8
ジャーナルOncology (Switzerland)
90
発行部数6
DOI
出版物ステータスPublished - 14-06-2016

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Cisplatin
Blood Pressure
Kidney
Blood Group Antigens
Hypoalbuminemia
Acute Kidney Injury
Drug Therapy
Cachexia
Glomerular Filtration Rate
Serum Albumin
Survival
Health
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Mizuno, T., Hayashi, T., Shimabukuro, Y., Murase, M., Hayashi, H., Ishikawa, K., ... Nagamatsu, T. (2016). Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity. Oncology (Switzerland), 90(6), 313-320. https://doi.org/10.1159/000446371
Mizuno, Tomohiro ; Hayashi, Takahiro ; Shimabukuro, Yuka ; Murase, Maho ; Hayashi, Hiroki ; Ishikawa, Kazuhiro ; Takahashi, Kazuo ; Yuzawa, Yukio ; Yamada, Shigeki ; Nagamatsu, Tadashi. / Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity. :: Oncology (Switzerland). 2016 ; 巻 90, 番号 6. pp. 313-320.
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title = "Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity",
abstract = "Background and Aims: Cisplatin-induced nephrotoxicity primarily occurs in the proximal tubules, and tubular injuries reduce glomerular filtration rates. Lower blood pressure causes renal hypoperfusion, which promotes ischemic acute kidney injury (AKI). Our study examined the relationship between lower blood pressure-induced renal hypoperfusion and cisplatin-induced nephrotoxicity. Methods: The relationship between cisplatin use and hypoalbuminemia is not clear. This study consisted of Japanese patients who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital from April 2006 to December 2012. Hypoalbuminemia was defined as serum albumin levels ≤3.5 mg/dl. Results: Patients who experienced lower blood pressure during chemotherapy were included in the lower blood pressure group (n = 229), and those who did not were included in the normal blood pressure group (n = 743). Total cisplatin dose in the normal blood pressure and lower blood pressure groups was 58.9 ± 23.8 and 55.0 ± 20.4 mg/m 2 , respectively. The rate of severe nephrotoxicity was higher and overall survival was shorter in the lower blood pressure group than in the normal blood pressure group. In a multivariable analysis, lower blood pressure significantly correlated with hypoalbuminemia. Conclusions: To prevent ischemic AKI, nutrition and cachexia controlling are important parts of cancer treatment.",
author = "Tomohiro Mizuno and Takahiro Hayashi and Yuka Shimabukuro and Maho Murase and Hiroki Hayashi and Kazuhiro Ishikawa and Kazuo Takahashi and Yukio Yuzawa and Shigeki Yamada and Tadashi Nagamatsu",
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Mizuno, T, Hayashi, T, Shimabukuro, Y, Murase, M, Hayashi, H, Ishikawa, K, Takahashi, K, Yuzawa, Y, Yamada, S & Nagamatsu, T 2016, 'Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity', Oncology (Switzerland), 巻. 90, 番号 6, pp. 313-320. https://doi.org/10.1159/000446371

Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity. / Mizuno, Tomohiro; Hayashi, Takahiro; Shimabukuro, Yuka; Murase, Maho; Hayashi, Hiroki; Ishikawa, Kazuhiro; Takahashi, Kazuo; Yuzawa, Yukio; Yamada, Shigeki; Nagamatsu, Tadashi.

:: Oncology (Switzerland), 巻 90, 番号 6, 14.06.2016, p. 313-320.

研究成果: Article

TY - JOUR

T1 - Lower blood pressure-induced renal hypoperfusion promotes cisplatin-induced nephrotoxicity

AU - Mizuno, Tomohiro

AU - Hayashi, Takahiro

AU - Shimabukuro, Yuka

AU - Murase, Maho

AU - Hayashi, Hiroki

AU - Ishikawa, Kazuhiro

AU - Takahashi, Kazuo

AU - Yuzawa, Yukio

AU - Yamada, Shigeki

AU - Nagamatsu, Tadashi

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Background and Aims: Cisplatin-induced nephrotoxicity primarily occurs in the proximal tubules, and tubular injuries reduce glomerular filtration rates. Lower blood pressure causes renal hypoperfusion, which promotes ischemic acute kidney injury (AKI). Our study examined the relationship between lower blood pressure-induced renal hypoperfusion and cisplatin-induced nephrotoxicity. Methods: The relationship between cisplatin use and hypoalbuminemia is not clear. This study consisted of Japanese patients who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital from April 2006 to December 2012. Hypoalbuminemia was defined as serum albumin levels ≤3.5 mg/dl. Results: Patients who experienced lower blood pressure during chemotherapy were included in the lower blood pressure group (n = 229), and those who did not were included in the normal blood pressure group (n = 743). Total cisplatin dose in the normal blood pressure and lower blood pressure groups was 58.9 ± 23.8 and 55.0 ± 20.4 mg/m 2 , respectively. The rate of severe nephrotoxicity was higher and overall survival was shorter in the lower blood pressure group than in the normal blood pressure group. In a multivariable analysis, lower blood pressure significantly correlated with hypoalbuminemia. Conclusions: To prevent ischemic AKI, nutrition and cachexia controlling are important parts of cancer treatment.

AB - Background and Aims: Cisplatin-induced nephrotoxicity primarily occurs in the proximal tubules, and tubular injuries reduce glomerular filtration rates. Lower blood pressure causes renal hypoperfusion, which promotes ischemic acute kidney injury (AKI). Our study examined the relationship between lower blood pressure-induced renal hypoperfusion and cisplatin-induced nephrotoxicity. Methods: The relationship between cisplatin use and hypoalbuminemia is not clear. This study consisted of Japanese patients who received cisplatin as the first-line chemotherapy at Fujita Health University Hospital from April 2006 to December 2012. Hypoalbuminemia was defined as serum albumin levels ≤3.5 mg/dl. Results: Patients who experienced lower blood pressure during chemotherapy were included in the lower blood pressure group (n = 229), and those who did not were included in the normal blood pressure group (n = 743). Total cisplatin dose in the normal blood pressure and lower blood pressure groups was 58.9 ± 23.8 and 55.0 ± 20.4 mg/m 2 , respectively. The rate of severe nephrotoxicity was higher and overall survival was shorter in the lower blood pressure group than in the normal blood pressure group. In a multivariable analysis, lower blood pressure significantly correlated with hypoalbuminemia. Conclusions: To prevent ischemic AKI, nutrition and cachexia controlling are important parts of cancer treatment.

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U2 - 10.1159/000446371

DO - 10.1159/000446371

M3 - Article

VL - 90

SP - 313

EP - 320

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 6

ER -