Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer

Sayumi Tahara, Tomomitsu Tahara, Noriyuki Horiguchi, Masaaki Okubo, Tsuyoshi Terada, Dai Yoshida, Kohei Funasaka, Yoshihito Nakagawa, Tomoyuki Shibata, Tetsuya Tsukamoto, Naoki Ohmiya

研究成果: Article

抄録

Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.

元の言語English
ページ(範囲)1651-1659
ページ数9
ジャーナルEpigenomics
11
発行部数15
DOI
出版物ステータスPublished - 11-2019

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Methylation
Stomach Neoplasms
CpG Islands
Pylorus
Gastric Mucosa
Phenotype
Mutation
Genes
Mucous Membrane
Genome

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cancer Research

これを引用

Tahara, Sayumi ; Tahara, Tomomitsu ; Horiguchi, Noriyuki ; Okubo, Masaaki ; Terada, Tsuyoshi ; Yoshida, Dai ; Funasaka, Kohei ; Nakagawa, Yoshihito ; Shibata, Tomoyuki ; Tsukamoto, Tetsuya ; Ohmiya, Naoki. / Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer. :: Epigenomics. 2019 ; 巻 11, 番号 15. pp. 1651-1659.
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abstract = "Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.",
author = "Sayumi Tahara and Tomomitsu Tahara and Noriyuki Horiguchi and Masaaki Okubo and Tsuyoshi Terada and Dai Yoshida and Kohei Funasaka and Yoshihito Nakagawa and Tomoyuki Shibata and Tetsuya Tsukamoto and Naoki Ohmiya",
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Tahara, S, Tahara, T, Horiguchi, N, Okubo, M, Terada, T, Yoshida, D, Funasaka, K, Nakagawa, Y, Shibata, T, Tsukamoto, T & Ohmiya, N 2019, 'Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer', Epigenomics, 巻. 11, 番号 15, pp. 1651-1659. https://doi.org/10.2217/epi-2019-0091

Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer. / Tahara, Sayumi; Tahara, Tomomitsu; Horiguchi, Noriyuki; Okubo, Masaaki; Terada, Tsuyoshi; Yoshida, Dai; Funasaka, Kohei; Nakagawa, Yoshihito; Shibata, Tomoyuki; Tsukamoto, Tetsuya; Ohmiya, Naoki.

:: Epigenomics, 巻 11, 番号 15, 11.2019, p. 1651-1659.

研究成果: Article

TY - JOUR

T1 - Lower LINE-1 methylation is associated with promoter hypermethylation and distinct molecular features in gastric cancer

AU - Tahara, Sayumi

AU - Tahara, Tomomitsu

AU - Horiguchi, Noriyuki

AU - Okubo, Masaaki

AU - Terada, Tsuyoshi

AU - Yoshida, Dai

AU - Funasaka, Kohei

AU - Nakagawa, Yoshihito

AU - Shibata, Tomoyuki

AU - Tsukamoto, Tetsuya

AU - Ohmiya, Naoki

PY - 2019/11

Y1 - 2019/11

N2 - Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.

AB - Aim: To investigate the associations between LINE1 methylation, an indicator for genome-wide hypomethylation, molecular and clinicopathological characteristics of gastric cancer (GC) patients. Patients & methods: LINE1 methylation statuses were examined in paired cancerous, non-neoplastic mucosa from 217 GC and gastric mucosa from separate group of 224 noncancer patients. CpG island methylator phenotype, TP53 and KRAS mutation, MLH1 methylation status and promoter hypermethylation of GC related and H. pylori-related genes were examined. Results: Lower LINE1 methylation was observed in primary GC compared with non-neoplastic gastric mucosa and associated with CpG island methylator phenotype, TP53 mutation, MLH1 methylation and promoter hypermethylation of GC related and H. pylori-related genes. Conclusion: Lower LINE1 methylation correlates specific molecular subtypes and promoter hypermethylation in GC.

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