TY - JOUR
T1 - Lowering barometric pressure aggravates mechanical allodynia and hyperalgesia in a rat model of neuropathic pain
AU - Sato, Jun
AU - Morimae, Hirohumi
AU - Seino, Yusuke
AU - Kobayashi, Taku
AU - Suzuki, Noriyuki
AU - Mizumura, Kazue
N1 - Funding Information:
We thank Dr. K. Koga and Mr. Y. Ota for their technical assistance, and thank Drs. G.J. Bennett and T. Kumazawa for their valuable comments on the manuscript. This work was partly supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Science and Culture, the Kato Ryutaro Foundation at Nagoya University and a part of ‘Ground Research for Space Utilization’ promoted by NASDA and The Japan Space Forum.
PY - 1999/4/30
Y1 - 1999/4/30
N2 - To examine the effects of meteorological change on the pain-related behaviors of neuropathic rats, animals with a chronic Constriction injury (CCI) to the sciatic nerve were exposed to low barometric pressure (LP), 20 mmHg below the natural atmospheric pressure in a climate-controlled room. CCI caused a decreased hindpaw withdrawal threshold to yon Frey hair (VFH) stimulation (mechanical allodynia) and prolonged duration of hindpaw withdrawal in response to pinprick stimulation (mechanical hyperalgesia). When the CCI rats were exposed to LP, both these pain-related behaviors were aggravated, whereas no change was seen in a group of controls. In the CCI rats sympathectomy inhibited this LP-induced augmentation of pain-related behaviors. These results show that LP intensifies the abnormalities in the pain-related behaviors of neuropathic rats, and that sympathetic activity contributes to the LP effect.
AB - To examine the effects of meteorological change on the pain-related behaviors of neuropathic rats, animals with a chronic Constriction injury (CCI) to the sciatic nerve were exposed to low barometric pressure (LP), 20 mmHg below the natural atmospheric pressure in a climate-controlled room. CCI caused a decreased hindpaw withdrawal threshold to yon Frey hair (VFH) stimulation (mechanical allodynia) and prolonged duration of hindpaw withdrawal in response to pinprick stimulation (mechanical hyperalgesia). When the CCI rats were exposed to LP, both these pain-related behaviors were aggravated, whereas no change was seen in a group of controls. In the CCI rats sympathectomy inhibited this LP-induced augmentation of pain-related behaviors. These results show that LP intensifies the abnormalities in the pain-related behaviors of neuropathic rats, and that sympathetic activity contributes to the LP effect.
UR - https://www.scopus.com/pages/publications/0344848715
UR - https://www.scopus.com/pages/publications/0344848715#tab=citedBy
U2 - 10.1016/S0304-3940(99)00260-8
DO - 10.1016/S0304-3940(99)00260-8
M3 - Article
C2 - 10336174
AN - SCOPUS:0344848715
SN - 0304-3940
VL - 266
SP - 21
EP - 24
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -
SDG 13 気候変動に具体的な対策を