Macrocystic and non-necrotic salivary duct carcinoma of the submandibular gland: A case report

Kenji Yorita, Katsushi Miyazaki, Makoto Urano, Toshitaka Nagao, Masato Nakaguro, Kazuhiko Tahara, Takashi Takeda, Kimiko Nakatani

研究成果: ジャーナルへの寄稿学術論文査読

抄録

Salivary duct carcinoma (SDC) is a major malignant salivary gland tumor that usually forms a solid tumor. Non-necrotic macrocystic SDCs have rarely been reported among salivary gland tumors. A 78-year-old Japanese man with a submandibular gland tumor was evaluated radiologically, pathologically, and immunohistochemically. A multilocular lesion with a maximum size of 6 cm was radiologically observed in the left submandibular region. It had been noticed 20 years earlier. Malignant cytological result was obtained, and surgical resection was performed. Pathological examination revealed a non-necrotic, macrocystic submandibular gland tumor lined with glandular, cribriform, or papillary forms of atypical cuboidal cells. Frankly invasive components were observed in intercystic areas. Intraductal, mucoepidermoid, and secretory carcinomas were identified as pathological differential diagnoses because of their macrocystic morphology. We diagnosed SDC because there was no intraductal growth based on the lack of myoepithelial markers, diffuse immunoreactivity to gross cystic disease fluid protein15, androgen receptor, and mammaglobin and immunonegativity to S100 and p63. Postoperative positron emission tomography revealed the absence of lymph node and distant metastases. The patient was disease-free 9 months after surgery. Salivary duct carcinoma can be included in the differential diagnoses of cystic salivary gland tumors.

本文言語英語
ページ(範囲)3049-3055
ページ数7
ジャーナルRadiology Case Reports
19
8
DOI
出版ステータス出版済み - 08-2024
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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