TY - JOUR
T1 - Macrocystic and non-necrotic salivary duct carcinoma of the submandibular gland
T2 - A case report
AU - Yorita, Kenji
AU - Miyazaki, Katsushi
AU - Urano, Makoto
AU - Nagao, Toshitaka
AU - Nakaguro, Masato
AU - Tahara, Kazuhiko
AU - Takeda, Takashi
AU - Nakatani, Kimiko
N1 - Publisher Copyright:
© 2024
PY - 2024/8
Y1 - 2024/8
N2 - Salivary duct carcinoma (SDC) is a major malignant salivary gland tumor that usually forms a solid tumor. Non-necrotic macrocystic SDCs have rarely been reported among salivary gland tumors. A 78-year-old Japanese man with a submandibular gland tumor was evaluated radiologically, pathologically, and immunohistochemically. A multilocular lesion with a maximum size of 6 cm was radiologically observed in the left submandibular region. It had been noticed 20 years earlier. Malignant cytological result was obtained, and surgical resection was performed. Pathological examination revealed a non-necrotic, macrocystic submandibular gland tumor lined with glandular, cribriform, or papillary forms of atypical cuboidal cells. Frankly invasive components were observed in intercystic areas. Intraductal, mucoepidermoid, and secretory carcinomas were identified as pathological differential diagnoses because of their macrocystic morphology. We diagnosed SDC because there was no intraductal growth based on the lack of myoepithelial markers, diffuse immunoreactivity to gross cystic disease fluid protein15, androgen receptor, and mammaglobin and immunonegativity to S100 and p63. Postoperative positron emission tomography revealed the absence of lymph node and distant metastases. The patient was disease-free 9 months after surgery. Salivary duct carcinoma can be included in the differential diagnoses of cystic salivary gland tumors.
AB - Salivary duct carcinoma (SDC) is a major malignant salivary gland tumor that usually forms a solid tumor. Non-necrotic macrocystic SDCs have rarely been reported among salivary gland tumors. A 78-year-old Japanese man with a submandibular gland tumor was evaluated radiologically, pathologically, and immunohistochemically. A multilocular lesion with a maximum size of 6 cm was radiologically observed in the left submandibular region. It had been noticed 20 years earlier. Malignant cytological result was obtained, and surgical resection was performed. Pathological examination revealed a non-necrotic, macrocystic submandibular gland tumor lined with glandular, cribriform, or papillary forms of atypical cuboidal cells. Frankly invasive components were observed in intercystic areas. Intraductal, mucoepidermoid, and secretory carcinomas were identified as pathological differential diagnoses because of their macrocystic morphology. We diagnosed SDC because there was no intraductal growth based on the lack of myoepithelial markers, diffuse immunoreactivity to gross cystic disease fluid protein15, androgen receptor, and mammaglobin and immunonegativity to S100 and p63. Postoperative positron emission tomography revealed the absence of lymph node and distant metastases. The patient was disease-free 9 months after surgery. Salivary duct carcinoma can be included in the differential diagnoses of cystic salivary gland tumors.
KW - Cystic neoplasm
KW - Intraductal carcinoma
KW - Salivary gland neoplasm
KW - Submandibular gland neoplasm
UR - http://www.scopus.com/inward/record.url?scp=85192243043&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85192243043&partnerID=8YFLogxK
U2 - 10.1016/j.radcr.2024.04.014
DO - 10.1016/j.radcr.2024.04.014
M3 - Article
AN - SCOPUS:85192243043
SN - 1930-0433
VL - 19
SP - 3049
EP - 3055
JO - Radiology Case Reports
JF - Radiology Case Reports
IS - 8
ER -