Macrophage signaling pathways: A novel target in renal disease

Frank Y. Ma, Yohei Ikezumi, David J. Nikolic-Paterson

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Monocytes/macrophages are a heterogeneous cell population that play a critical role in host defense and tissue homeostasis. However, macrophage activation during acute and chronic inflammation can result in macrophage-mediated renal injury in a variety of settings, including proliferative glomerulonephritis. Macrophages can be activated via a number of intracellular signaling pathways (eg, c-Jun amino terminal kinase, p38 mitogen-activated protein kinase, FcR/Syk, Janus kinase/signal transducer and activator of transcription) that induce production of mediators of renal injury. Thus, targeting selected macrophage signaling pathways is a potential therapeutic strategy to suppress macrophage-mediated renal injury while leaving intact the desirable macrophage functions of host defense and tissue repair.

本文言語English
ページ(範囲)334-344
ページ数11
ジャーナルSeminars in Nephrology
30
3
DOI
出版ステータスPublished - 05-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腎臓病学

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