Magnifying endoscope with NBI to predict the depth of invasion in laryngo-pharyngeal cancer

Ichiro Tateya, Shuko Morita, Manabu Muto, Shin'Ichi Miyamoto, Tomomasa Hayashi, Makiko Funakoshi, Ikuo Aoyama, Shigeru Hirano, Morimasa Kitamura, Seiji Ishikawa, Yo Kishimoto, Mami Morita, Patnarin Mahattanasakul, Satoshi Morita, Juichi Ito

研究成果: ジャーナルへの寄稿学術論文査読

34 被引用数 (Scopus)

抄録

Objectives/Hypothesis To examine if macroscopic classification with a magnifying gastrointestinal endoscope with narrow band imaging (ME-NBI) is useful in predicting pathological depth of tumor invasion in laryngo-pharyngeal cancer. Study Design Retrospective study. Methods Preoperative endoscopy reports and postoperative pathological reports on 139 laryngo-pharyngeal cancer lesions were retrospectively reviewed, and the association between macroscopic findings in the lesions and the depth of tumor invasion was analyzed statistically. Results The ratios of lesions macroscopically classified as 0-I (superficial and protruding), 0-IIa (slightly elevated), 0-IIb (true flat), 0-IIc (slightly depressed), and 0-III (superficial and excavated) in the preoperative endoscopy reports were 3%, 25%, 71%, 1%, and 0%, respectively. Regarding the depth of tumor invasion in the postoperative pathological reports, the ratios of lesions classified as EP (carcinoma in situ), SEP (tumor invades subepithelial layer), and MP (tumor invades muscularis propria) were 73%, 26%, and 1%, respectively. The ratios of subepithelial invasion or muscular invasion in 0-I, 0-IIa, and 0-IIb were 100%, 54%, and 14%, respectively, and showed significant difference (P<0.0001). Only one of 139 lesions invaded the muscular propria. Conclusions This study is the first one to show that macroscopic findings by ME-NBI predict the depth of tumor invasion in superficial laryngo-pharyngeal cancer. It was indicated that there is a little chance of muscular invasion if the lesion is endoscopically diagnosed as 0-I or 0-II. A new T stage classification based on the depth of tumor invasion may be needed in order to adapt the classification to include transoral surgery.

本文言語英語
ページ(範囲)1124-1129
ページ数6
ジャーナルLaryngoscope
125
5
DOI
出版ステータス出版済み - 01-05-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 耳鼻咽喉科学

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