Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk

Tomomitsu Tahara, Sayumi Tahara, Tetsuya Tuskamoto, Noriyuki Horiguchi, Dai Yoshida, Tomohiko Kawamura, Masaaki Okubo, Mitsuo Nagasaka, Yoshihito Nakagawa, Makoto Urano, Makoto Kuroda, Tomoyuki Shibata, Naoki Ohmiya

研究成果: Article

3 引用 (Scopus)

抄録

Background: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. Materials and Methods: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels. The subjects were also classified into the three types: Grade 0—restored pattern is shown in all or almost the entire area of gastric body; Grade 1—mixture of restored and atrophic pattern, there is a considerable portion of the atrophic area in the lesser curvature; Grade 2—atrophic pattern is shown in all or almost the entire area of the gastric body. Results: Sensitivity and specificity for atrophic type for detection of histological intestinal metaplasia were 95.9 and 98.3%, respectively. No association was observed between the prevalence of Grades 0, 1 and 2 and duration after eradication, while grades 1 and 2 were significantly frequent in gastric cancer patients diagnosed both before (27/35: 77%) and after (23/31: 74%) eradication, compared to the cancer-free subjects (15/59: 25%) (P < 0.001). The grades 1 and 2 were also common in patients who underwent H. pylori eradication for gastric ulcer. Conclusions: Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence.

元の言語English
ページ(範囲)2421-2427
ページ数7
ジャーナルDigestive Diseases and Sciences
62
発行部数9
DOI
出版物ステータスPublished - 01-09-2017

Fingerprint

Gastric Mucosa
Helicobacter pylori
Stomach Neoplasms
Stomach
Atrophic Gastritis
Metaplasia
Stomach Ulcer
Endoscopy
Sensitivity and Specificity
Neoplasms

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

これを引用

Tahara, Tomomitsu ; Tahara, Sayumi ; Tuskamoto, Tetsuya ; Horiguchi, Noriyuki ; Yoshida, Dai ; Kawamura, Tomohiko ; Okubo, Masaaki ; Nagasaka, Mitsuo ; Nakagawa, Yoshihito ; Urano, Makoto ; Kuroda, Makoto ; Shibata, Tomoyuki ; Ohmiya, Naoki. / Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk. :: Digestive Diseases and Sciences. 2017 ; 巻 62, 番号 9. pp. 2421-2427.
@article{7a6acfa24e2241c4bd76d1c33cac4587,
title = "Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk",
abstract = "Background: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. Materials and Methods: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels. The subjects were also classified into the three types: Grade 0—restored pattern is shown in all or almost the entire area of gastric body; Grade 1—mixture of restored and atrophic pattern, there is a considerable portion of the atrophic area in the lesser curvature; Grade 2—atrophic pattern is shown in all or almost the entire area of the gastric body. Results: Sensitivity and specificity for atrophic type for detection of histological intestinal metaplasia were 95.9 and 98.3{\%}, respectively. No association was observed between the prevalence of Grades 0, 1 and 2 and duration after eradication, while grades 1 and 2 were significantly frequent in gastric cancer patients diagnosed both before (27/35: 77{\%}) and after (23/31: 74{\%}) eradication, compared to the cancer-free subjects (15/59: 25{\%}) (P < 0.001). The grades 1 and 2 were also common in patients who underwent H. pylori eradication for gastric ulcer. Conclusions: Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence.",
author = "Tomomitsu Tahara and Sayumi Tahara and Tetsuya Tuskamoto and Noriyuki Horiguchi and Dai Yoshida and Tomohiko Kawamura and Masaaki Okubo and Mitsuo Nagasaka and Yoshihito Nakagawa and Makoto Urano and Makoto Kuroda and Tomoyuki Shibata and Naoki Ohmiya",
year = "2017",
month = "9",
day = "1",
doi = "10.1007/s10620-017-4676-x",
language = "English",
volume = "62",
pages = "2421--2427",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "9",

}

Tahara, T, Tahara, S, Tuskamoto, T, Horiguchi, N, Yoshida, D, Kawamura, T, Okubo, M, Nagasaka, M, Nakagawa, Y, Urano, M, Kuroda, M, Shibata, T & Ohmiya, N 2017, 'Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk', Digestive Diseases and Sciences, 巻. 62, 番号 9, pp. 2421-2427. https://doi.org/10.1007/s10620-017-4676-x

Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk. / Tahara, Tomomitsu; Tahara, Sayumi; Tuskamoto, Tetsuya; Horiguchi, Noriyuki; Yoshida, Dai; Kawamura, Tomohiko; Okubo, Masaaki; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Urano, Makoto; Kuroda, Makoto; Shibata, Tomoyuki; Ohmiya, Naoki.

:: Digestive Diseases and Sciences, 巻 62, 番号 9, 01.09.2017, p. 2421-2427.

研究成果: Article

TY - JOUR

T1 - Magnifying NBI Patterns of Gastric Mucosa After Helicobacter pylori Eradication and Its Potential Link to the Gastric Cancer Risk

AU - Tahara, Tomomitsu

AU - Tahara, Sayumi

AU - Tuskamoto, Tetsuya

AU - Horiguchi, Noriyuki

AU - Yoshida, Dai

AU - Kawamura, Tomohiko

AU - Okubo, Masaaki

AU - Nagasaka, Mitsuo

AU - Nakagawa, Yoshihito

AU - Urano, Makoto

AU - Kuroda, Makoto

AU - Shibata, Tomoyuki

AU - Ohmiya, Naoki

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. Materials and Methods: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels. The subjects were also classified into the three types: Grade 0—restored pattern is shown in all or almost the entire area of gastric body; Grade 1—mixture of restored and atrophic pattern, there is a considerable portion of the atrophic area in the lesser curvature; Grade 2—atrophic pattern is shown in all or almost the entire area of the gastric body. Results: Sensitivity and specificity for atrophic type for detection of histological intestinal metaplasia were 95.9 and 98.3%, respectively. No association was observed between the prevalence of Grades 0, 1 and 2 and duration after eradication, while grades 1 and 2 were significantly frequent in gastric cancer patients diagnosed both before (27/35: 77%) and after (23/31: 74%) eradication, compared to the cancer-free subjects (15/59: 25%) (P < 0.001). The grades 1 and 2 were also common in patients who underwent H. pylori eradication for gastric ulcer. Conclusions: Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence.

AB - Background: Gastric cancer develops after successful H. pylori eradication in patients with severe atrophic gastritis. We classified atrophic and non-atrophic mucosa of gastric body using magnifying NBI endoscopy in patients after successful H. pylori eradication. Materials and Methods: One hundred and twenty-five patients after successful H. pylori eradication (median period after eradication: 36 months) were enrolled. Magnifying NBI patterns in the uninvolved gastric body were divided into the following: restored-small, round pits, accompanied with honeycomb-like subepithelial capillary networks; atrophic-well-demarcated oval or tubulovillous pits with clearly visible coiled or wavy vessels. The subjects were also classified into the three types: Grade 0—restored pattern is shown in all or almost the entire area of gastric body; Grade 1—mixture of restored and atrophic pattern, there is a considerable portion of the atrophic area in the lesser curvature; Grade 2—atrophic pattern is shown in all or almost the entire area of the gastric body. Results: Sensitivity and specificity for atrophic type for detection of histological intestinal metaplasia were 95.9 and 98.3%, respectively. No association was observed between the prevalence of Grades 0, 1 and 2 and duration after eradication, while grades 1 and 2 were significantly frequent in gastric cancer patients diagnosed both before (27/35: 77%) and after (23/31: 74%) eradication, compared to the cancer-free subjects (15/59: 25%) (P < 0.001). The grades 1 and 2 were also common in patients who underwent H. pylori eradication for gastric ulcer. Conclusions: Magnifying the NBI pattern well correlates with pathological status of gastric mucosa after H. pylori eradication and may predict gastric cancer occurrence.

UR - http://www.scopus.com/inward/record.url?scp=85023182691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023182691&partnerID=8YFLogxK

U2 - 10.1007/s10620-017-4676-x

DO - 10.1007/s10620-017-4676-x

M3 - Article

C2 - 28702753

AN - SCOPUS:85023182691

VL - 62

SP - 2421

EP - 2427

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 9

ER -