Mannosidase, alpha, class 2a2 (MAN2A2)

Michiko N. Fukuda, Kazuhiro Sugihara, Tomoya O. Akama

研究成果: Chapter

抄録

Many proteins synthesized through the secretory pathway are posttranslationally modified by N-glycosylation. Alpha-mannosidase II (MAN2A1) and alpha-mannosidase IIx (MAN2A2) are key enzymes that convert precursor high mannose-type N-glycans to mature complex-type structures. While alpha-mannosidase II activity had been characterized by the time the mechanism of N-glycan processing was recognized (Kornfeld and Kornfeld 1985), investigators did not discover an alternative processing pathway until Man2a1 null mutant mice were generated and found capable of synthesizing complex-type N-glycans (Chui et al. 1997). Man2a2 then became a candidate for mediating that alternate pathway of N-glycan synthesis, but support for the pathway was lacking until creation of Man2a1/Man2a2 double knockout mice, which showed a complete loss in the ability to synthesize complex-type N-glycans (Fig. 117.1) (Akama et al. 2006).

本文言語English
ホスト出版物のタイトルHandbook of Glycosyltransferases and Related Genes, Second Edition
出版社Springer Japan
ページ1327-1333
ページ数7
2
ISBN(電子版)9784431542407
ISBN(印刷版)9784431542391
DOI
出版ステータスPublished - 01-01-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Mannosidase, alpha, class 2a2 (MAN2A2)」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル