Mantle cell lymphoma with a unique pattern of CD5 expression: a case report with review of the literatures

Toshiki Yamada, Naoe Goto, Hisashi Tsurumi, Katsuyoshi Takata, Yasuharu Sato, Tadashi Yoshino, Hisataka Moriwaki, Yusuke Kito, Tamotsu Takeuchi, Hitoshi Iwata

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Mantle cell lymphoma (MCL) is a unique subtype of B-cell non-Hodgkin’s lymphoma characterized by chromosomal translocation t(11;14)(q13;q32), positive CD5, and nuclear cyclin D1 overexpression with unfavorable prognosis. We report herein a case of MCL in a 73-year-old male diagnosed with diffuse large B-cell lymphoma (ileal tumor) at another hospital, who subsequently relapsed with CD5-negative MCL. At the 1st relapse, he developed neck lymph node swelling, of which biopsy showed proliferation of atypical large pleomorphic cells with CD5-negativity by both immunohistochemistry and flow cytometry. At the 2nd relapse, he again developed an ileal tumor, of which biopsy showed positivity for CD5, CD20, and cyclin D1. In MCL, CD5-negative expression has sometimes been reported as having pleomorphic and blastoid variants. The present case was also histologically the pleomorphic type, but the CD5 expression changed from negative at the onset and the 1st relapse to positive at the 2nd relapse. This is a rare and interesting case because of the different expression of CD5 at all stage. This phenomenon made the diagnosis of MCL difficult.

本文言語English
ジャーナルMedical Molecular Morphology
47
3
DOI
出版ステータスPublished - 09-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 分子生物学

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