Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease

Rieko Okada, Sayo Kawai, Mariko Naito, Asahi Hishida, Nobuyuki Hamajima, Koichi Shinchi, Tanvir Chowdhury Turin, Sadao Suzuki, Eva Mariane Mantjoro, Kengo Toyomura, Kokichi Arisawa, Nagato Kuriyama, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai

研究成果: Article

12 引用 (Scopus)

抜粋

Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9-1562T/279R/668Q showed a reduced risk for CKD compared with the most common-1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination-1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous-1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases.

元の言語English
ページ(範囲)444-450
ページ数7
ジャーナルAmerican Journal of Nephrology
36
発行部数5
DOI
出版物ステータスPublished - 01-11-2012

All Science Journal Classification (ASJC) codes

  • Nephrology

フィンガープリント Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Okada, R., Kawai, S., Naito, M., Hishida, A., Hamajima, N., Shinchi, K., Chowdhury Turin, T., Suzuki, S., Mantjoro, E. M., Toyomura, K., Arisawa, K., Kuriyama, N., Hosono, S., Mikami, H., Kubo, M., Tanaka, H., & Wakai, K. (2012). Matrix metalloproteinase-9 gene polymorphisms and chronic kidney disease. American Journal of Nephrology, 36(5), 444-450. https://doi.org/10.1159/000343742