Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy

Hiroyuki Mizoguchi, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Review article査読

47 被引用数 (Scopus)

抄録

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.

本文言語English
論文番号681385
ジャーナルBiochemistry Research International
DOI
出版ステータスPublished - 2011

All Science Journal Classification (ASJC) codes

  • 生化学

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