Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer's disease, and epilepsy

Hiroyuki Mizoguchi, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Review article

39 引用 (Scopus)

抜粋

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors that mediate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Interestingly, increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathologic conditions. In this paper, we discuss various animal models that suggest that the activation of the gelatinases MMP-2 and MMP-9 is involved in pathogenesis of drug dependence, Alzheimer's disease, and epilepsy.

元の言語English
記事番号681385
ジャーナルBiochemistry Research International
DOI
出版物ステータスPublished - 01-12-2011
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Biochemistry

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